正交试验法优选芩榆烧伤液提取工艺研究  

A Study on the Extraction Technology of Qinyu Solution for Burns

作　　者：李维强 王云飞 苏庆[3] 薛桂蓬 毛艳 贺金华 

机构地区：[1]解放军69220部队医院 [2]新疆维吾尔自治区药物研究所 [3]总后勤部卫生部药品仪器检验所

出　　处：《解放军药学学报》2011年第4期293-295,共3页Pharmaceutical Journal of Chinese People's Liberation Army

基　　金：新疆自治区高技术研究发展计划项目;No.201110105

摘　　要：目的研究芩榆烧伤液提取工艺,优选最佳工艺条件。方法以黄芩苷含量为检测指标,用正交法考察3种因素（乙醇浓度、加醇倍量、渗漉速度）对含量的影响。结果黄芩苷在10.36-51.8μg/ml范围内线性关系良好（r=0.9993,n=5）。最佳提取工艺为A2B2C1,即30倍量60%乙醇,以7 ml/min的流速进行渗漉。结论该提取工艺设计合理,结果可靠,可用于芩榆烧伤液的制备。Objective To optimize the extraction process of Qinyu Solution for Burns.Methods The content of baicalin was adopted as the index and determined by high performance liquid chromatography.Orthogonal-test L9（34） was employed to optimize the extraction technology.Results The content of baicalin showed a good linear relationship within the range of 10.36-51.8 μg/ml（r=0.9993,n=5）.The optimal extraction technology was adding 30 times the amount of 60% alcohol at the extraction rate 7 ml/min.Conclusion This extraction technology is feasible and applicable for the preparation of Qinyu Solution for Burns.

关 键 词：芩榆烧伤液 渗漉法 提取工艺 正交试验 

分 类 号：R943[医药卫生—药剂学]