血清γ-谷氨酰转肽酶对淤胆型婴儿肝病的诊断价值  被引量:2

Diagnostic value of serum gamma glutamyltransferase on infantile cholestatic hepatopathy

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作  者:刘海燕[1] 高金星[1] 袁晓云[1] 

机构地区:[1]解放军第161中心医院,湖北武汉430010

出  处:《现代中西医结合杂志》2011年第26期3264-3265,3322,共3页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘  要:目的探讨血清γ-谷氨酰转肽酶(GGT)活性测定对淤胆型婴儿肝病的诊断价值。方法采集86例淤胆型肝病患儿血清,以80例正常婴儿为对照,常规生化检测,包括血液总胆红素(TBil)、直接胆红素(DBil)、丙氨酸转氨酶(ALT)、谷氨酸转氨酶(AST)、碱性磷酸酶(ALP)、总胆汁酸的活性,对其结果进行比较。结果淤胆型婴儿肝病组TBil增高明显,以DBil增高为主。TBil平均值为176.04μmol/L、DBil平均值为106.42μmol/L,平均DBil值占平均TBil值的60.45%。正常对照组血清GGT测定结果为(26.64±15.92)IU/L,淤胆型婴儿肝病组为(224.53±177.32)IU/L,显著高于正常对照组(P<0.01),异常率为92%。淤胆型婴儿肝病GGT水平与血清中TBil、ALP和TBA水平有一定程度的相关性。结论血清GGT测定对淤胆型婴儿肝病的辅助诊断具有十分重要的意义,具有较高的特异性和敏感性。Objective It is to approach the diagnostic value of serum gamma glutamyltransferase(GGT) activity determination on infantile cholestatic hepatopathy.Methods Eighty-six cases of infantile cholestatic hepatopathy were given conventional serum biochemistry detection and 80 cases of normal infants were as control.The detection items included total bilirubin(TBil),direct bilirubin(DBil),Alaninetransaminase(ALT),Aspartatetransaminase(AST),alkaline phosphatase(ALP) and total bile acid(TBA).The results were compared.Results TBil in infantile cholestatic hepatopathy group heightened obviously,of all mainly was DBil.The average of TBil was 176.04 μmol/L and that of DBil was 106.42 μmol/L.In average TBil,the average DBil was 60.45%.GGT in normal control group was(26.64±15.92) IU/L and that in infantile cholestatic hepatopathy group was(224.53±177.32) IU/L,and that in infantile cholestatic hepatopathy group was significantly higher than that in normal control group(P0.01),and the abnormal rate was 92%.Serum GGT level in infantile cholestatic hepatopathy had determinate correlation with TBil,ALP and TBA.Conclusion Serum GGT detection has fully important significance to be subsidiary diagnosis of infantile cholestatic hepatopathy,which has a high sensitivity and specificity.

关 键 词:肝病综合征 婴儿 Γ-谷氨酰转肽酶 胆汁淤积 

分 类 号:R725.7[医药卫生—儿科]

 

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