282例β-内酰胺类抗菌药的不良反应分析  

Analysis for 282 Cases of Adverse Drug Reaction of β-lactam Antibiotics

作　　者：潘海燕[1] 凌春燕[1] 朱青[1] 

机构地区：[1]南京大学医学院附属鼓楼医院药剂科,南京210008

出　　处：《药物流行病学杂志》2011年第8期401-403,共3页Chinese Journal of Pharmacoepidemiology

摘　　要：目的:了解我院2009～2010年β-内酰胺类抗菌药不良反应发生情况,分析其影响因素,以促进临床合理用药。方法:收集我院2009～2010年上报告国家药品不良反应监测中心的282例β-内酰胺类抗菌药的药品不良反应(ADR)报告,分别从患者年龄、性别、给药途径、使用药物种类以及临床表现等方面进行统计分析。结果:ADR涉及β-内酰胺类抗菌药共33种,以头孢曲松居首位,其次为头孢呋辛和氨曲南;以静脉途径给药引发的ADR最多;282例ADR中,大于60岁患者构成比最高(28.72%);临床表现以皮肤及其附件损害最常见。结论:β-内酰胺类抗菌药发生ADR与年龄、给药途径等多种因素相关,应规范β-内酰胺类抗菌药的临床应用,减少ADR的发生。Objective：To investigate the reality and affecting factors of adverse drug reaction（ADR ） induced by β-1actam antibiotics in our hospital during 2009-2010, in order to promote the rational use of drug in clinic. Method： We classified and analyzed 282 cases of ADR of β-lactam antibiotics which is reported to National center for ADR Monitoring during 2009 -2010, according to the aspects of patients＇age and gender, administration route, species of drugs and clinical manifestations. Result：The ADR were caused by a total of 33 species of β-lactam antibiotics agents, amongwhich Ceftriaxone ranked the first and was followed by Cefuroxime and Aztreonam; The most causing routewas intravenous administration; of which, those patients＇ aged above 60 years accounted for 28.72% ;the damage of skin and its annex were the most common clinical manifestations. Conclusion：Multiple factors contributed to the ADR, for example age and administration route. And the clinical application of β-lactam antibiotics of should be regulated to avoid or reduce the occurrence of ADR.

关 键 词：β-内酰胺类抗菌药 药品不良反应 合理用药 

分 类 号：R978.11[医药卫生—药品]