托烷司琼与氟哌利多复合地塞米松对腹腔镜胆囊切除术后恶心呕吐的对比  

Comparation the prophylactic effect of tropisetron and droperidol combined with dexamethasone on postoperative nausea and vomiting after laparoscopic cholecystectomy

作　　者：陆晓刚 李晖 王燕琼[2] 

机构地区：[1]武警云南总队医院麻醉科,昆明650111 [2]昆明市第一人民医院麻醉科

出　　处：《临床医学》2011年第8期18-20,共3页Clinical Medicine

摘　　要：目的比较托烷司琼、氟哌利多复合地塞米松预防腹腔镜胆囊切除术后恶心、呕吐的效果。方法择期腹腔镜胆囊切除术患者120例(ASAⅠ～Ⅱ级),于麻醉前随机分为三组,每组40例。A组:托烷司琼2 mg(加盐水稀释至3 ml);B组:氟哌利多2.5 mg+地塞米松10 mg(共3 ml);C组:生理盐水3 ml。观察术后24 h恶心、呕吐发生率并对两组进行对比。结果三组术后24 h恶心、呕吐总发生率分别为:A组25%,B组30%,C组75%。A组和B组术后恶心、呕吐的发生率均明显低于C组(P<0.01),而A组与B组间比较差异无统计学意义(P>0.05)。结论托烷司琼、氟哌利多复合地塞米松对腹腔镜胆囊切除术后恶心、呕吐都有较好的预防作用,但托烷司琼价格昂贵,相比而言氟哌利多复合地塞米松更显示其性价比优越性。Objective To compare the prophylactic effect of tropisetron and droperidol combined with dexamethasone on postoperative nausea and vomiting（PONV） after laparoscopic cholecystectomy（LC）.Methods One hundred and twenty ASAⅠorⅡpatients scheduled for LC were randomly divided into three groups with 40 cases each.The patient s in group A received a single preanaesthesia intravenous does of tropisetron 2 mg（add 0.9% NS to 3 ml）,and in group B droperidol 2.5 mg plus dexamethasone 10 mg（total 3 ml） and in group C 0.9%NS 3 ml.Observed the incidence of PONV in the 24 h.Results The PONV incidences of group A,B,C were 25%,30% and 75%.Both group A and group B significantly decreased the total incidences of PONV（P0.05）in the 24 hours.But there was no marked difference between group A and B.Conclusion Tropisetron and combination of droperidol and dexamethasone can significantly reduce the incidence of PONV after LC.But the value-capability ratio of droperidol plus dexamethasone is better than tropisetron.

关 键 词：术后恶心呕吐 腹腔镜胆囊切除术 托烷司琼 氟哌利多 地塞米松 

分 类 号：R614[医药卫生—麻醉学]