非白念珠菌和白念珠菌感染危险因素的对比研究  

ANALYSIS OF RISK FACTORS OF CANDIDA ALBICANS VERSUS NON-ALBICANS INFECTIONS

作　　者：冯文莉[1] 王艳青[1] 奚志琴[1] 杨静[1] 张润梅[2] 冀英[1] 吴媛[1] 贾晓强[1] 

机构地区：[1]山西医科大学第二医院皮肤性病科,太原030001 [2]山西医科大学第二医院药敏室

出　　处：《现代预防医学》2011年第17期3400-3404,共5页Modern Preventive Medicine

基　　金：山西省科技攻关项目资助(2007031091-9);山西医科大学创新基金项目资助(01201013)

摘　　要：[目的]探讨住院患者非白念珠菌感染和白念珠菌感染的流行病学特点以及发生的相关危险因素。[方法]采用病例对照研究方法,对256例非白念珠菌感染者、834例白念珠菌感染者以及1220例无真菌感染者进行危险因素比较,应用SPSS13.0统计软件进行统计学分析。[结果]年龄、病程、住院时间、白细胞及中性粒细胞计数减少、白蛋白降低、基础疾病、预防性使用抗真菌药物、抗菌素、激素、免疫抑制剂、有创的检查和治疗是白念珠菌和非白念珠菌感染的共同危险因素。患有泌尿系统疾病、使用激素更容易引起非白念珠菌感染,使用免疫抑制剂更容易引起白念珠菌感染。[结论]念珠菌感染的流行病学是复杂而变化的,白念珠菌和非白念珠菌感染的危险因素也是不同的。非白念珠菌感染已经成为一个不容忽视的问题。早期诊治基础疾病、合理规范应用检查和治疗手段、适当缩短住院时间是预防念珠菌感染的关键。[Objective]To identify differences in risk factors and outcomes in hospital patients with Candida albicans and non-albicans infections.[Methods]A prospective case-control study was conducted to compare risk factors of 834 cases of Candida albicans,256 cases of non-albicans infections and 1 220 cases of non-IFI in hospital patients of the Second Hospital of Shanxi Medical University.The risk factors of Candida albicans and non-albicans infections were analyzed by method of SPSS13.0 model.[Results]Univariate analysis and multivariate logistic regression analysis showed that age,course of disease,length of hospitalization,leucocyte count reducing,neutrocyte count reducing,albumin reducing,basic disease,prophylactic antifungal drugs,antibiotics,glucocorticoids,immunosuppressants,invasive examination and treatment were the risk factors for Candida albicans and non-albicans infections.Suffering from diseases of the urinary system,using of glucocorticoids more easily lead to non-albicans infections,but using the immunodepressants was more vulnerable to infection caused by Candida albicans.[Conclusion]The epidemiology of candida infections is complex and varies among the different patients in hospital.The risk factors ate different between Candida albicans and non-albicans infections.Non-albicans infection was important in hospital patients.To efficiently control the risk factors should be emphasized,including early diagnosis,treatment of basic diseases,appropriate examine,prudent drug use,and shortening hospitalization.

关 键 词：住院患者 非白念珠菌 白念珠菌 危险因素 

分 类 号：R379.4[医药卫生—病原生物学]