超声随访复查对阿苯达唑治疗肝包虫病的疗效观察  

B-ULTRASOUND EXAMINATION ON RESULT ANALYSIS WITH ALBENDAZOLE TREATMENT IN HEPATIC ECHINOCOCCOSIS

作　　者：冯运灵[1] 吴向林[1] 李丽[1] 马玉秀[2] 路宗仁[3] 张敏[1] 

机构地区：[1]宁夏疾病预防控制中心,银川750004 [2]宁夏平罗县疾病预防控制中心 [3]宁夏西吉县疾病预防控制中心

出　　处：《现代预防医学》2011年第17期3556-3557,3560,共3页Modern Preventive Medicine

基　　金：宁夏科技攻关项目(KGX-19-07-01)

摘　　要：[目的]对比分析肝包虫病患者阿苯达唑治疗1年前后的超声影像结果,评价阿苯达唑对肝包虫病的疗效。[方法]采用前瞻性队列研究方法,对肝包虫病确诊病例给予阿苯达唑治疗1年后同法复查,对比分析治疗前后的B超影像变化。[结果]阿苯达唑对肝包虫病治疗总有效率83.70%(534/638),其中对囊型肝包虫病治疗有效率83.90%(516/615),对泡型肝包虫病治疗有效率78.26%(18/23),二者间疗效无差异(χ2=0.186,P﹥0.05);阿苯达唑片剂治疗有效率78.67%(273/347),乳剂治疗有效率89.69%(261/291),乳剂的疗效好于片剂(χ2=14.08,P﹤0.05);阿苯达唑对黄疸﹑腹水改善较明显(χ2=8.08,P﹤0.05)。[结论]阿苯达唑对肝包虫病有较好疗效,可做为包虫病首选治疗药物;B型超声检查可用于阿苯达唑治疗肝包虫病的疗效评价。[Objective]To compare the outcomes of albendazole treatment in hepatic hydatid disease,to evaluate the albendazole efficacy of albendazole.[Methods]Adopted a prospective randomized research method﹐used the same methods in re-examination after 1 year for serological tests（ELISA）-positive and confirmed by B-ultrasound examination of liver hydatid disease who were treated with albendazole﹐according to the change of B-ultrasound and clinical symptoms,evaluated the treatment effects.[Results]The total effective rate of Albendazole treatment in hepatic echinococcosis was 83.70%.The efficiency rate of albendazole treatment on cystic echinococcosis was 83.90%﹐ and on alveolar echinococcosis was 78.26%﹐by statistically testing the difference between the two diseases was not significant（χ2 = 0.186,P﹥0.05）;the efficiency rate of tablet treatment was 78.67%﹐and emulsion treatment was 89.69%,by statistically testing the difference between emulsion and tablets treatment was significant（χ2 = 14.08,P﹤0.05）;improvements of jaundice and ascites were obvious（χ2 = 8.08,P﹤0.05）.[Conclusion]Albendazole on hydatid disease has a better therapeutic effect,which can be used as the preferred therapy for echinococcosis﹐ B-ultrasound examination can be used to evaluate the albendazole treatment effect for liver hydatid disease.

关 键 词：阿苯达唑 肝包虫病 疗效观察 超声随访 

分 类 号：R978[医药卫生—药品]