穿心莲内酯对小鼠腹泻模型的治疗作用研究  

Study on the Anti-diarrhea Effect of Andrographolide in Mice

作　　者：张程亮[1] 王砚 向道春[1] 刘东[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院药学部,武汉430030 [2]湖北省荆门市石化医院药剂科

出　　处：《中国药师》2011年第8期1102-1105,共4页China Pharmacist

摘　　要：目的:研究穿心莲内酯对番泻叶和蓖麻油所致小鼠腹泻模型的治疗作用。方法:以墨汁推进率为指标,观察穿心莲内酯对小鼠小肠推进性运动的影响;分别采用番泻叶和蓖麻油建立小鼠腹泻模型,观察穿心莲内酯给药组小鼠的一般状态及行为学改变,测定稀便率及腹泻指数,并计算单位长度肠质量,评价穿心莲内酯的抗腹泻作用。结果:穿心莲内酯可减缓小鼠小肠推进运动(P<0.05)。与模型对照组相比,150mg·kg^(-1)的穿心莲内酯可降低番泻叶和蓖麻油所致小鼠腹泻模型的稀便率(P<0.05),不同剂量的穿心莲内酯均可降低两种模型中小鼠的腹泻指数(P<0.05)。穿心莲内酯可分别降低番泻叶所致小鼠模型的大肠单位肠重和蓖麻油所致小鼠模型的小肠单位肠重(P<0.05)。结论:穿心莲内酯可有效缓解番泻叶和蓖麻油所致小鼠的腹泻,机制可能与抑制肠道推进功能,减少肠道分泌有关。Objective：To investigate the therapeutic activity of andrographolide on diarrhea induced by senna and castor oil in mice.Method：The effect of andrographolide on intestinal propulsive motility of mice was observed by the movement rate of ink in the intestine.To assess the antidiarrheal effect,the diarrhea models were induced by senna or castor oil.The general state and behaviors of mice,loose stools rate,diarrhea index and intestine weight per unit length were investigated to evaluate the therapeutic effect of andrographolide on diarrhea.Result：Intestinal propulsive motility of mice was decreased by andrographolide（P〈0.05）.Compared with the model control group,the loose stools rate of the diarrhea models induced by either senna or castor oil was reduced by andrographolide with the oral dose of 150 mg？kg^（-1）（P〈0.05）.The diarrhea indices in the two diarrhea models were both decreased by different doses of andrographolide（P〈0.05）.Large intestine weight per unit length in senna-induce diarrhea model was decreased by andrographolide （P〈0.05）,while the similar effect was observed on small intestine weight per unit length in castor oil-induce diarrhea model （P〈0.05）.Conclusion：Andrographolide can relief the diarrhea induced by senna or castor oil in mice.The underlying mechanism may be related with its inhibition on the intestinal propulsive motility and secretion.

关 键 词：穿心莲内酯 腹泻 番泻叶 蓖麻油 

分 类 号：R285.5[医药卫生—中药学]