1201例次地高辛血浓度监测结果分析  

Analysis of Serum Concentrations of Digoxin in 1201 Samples

作　　者：王君萍[1] 杜贯涛[1] 

机构地区：[1]常州市第二人民医院,江苏常州213003

出　　处：《中国药师》2011年第8期1159-1161,共3页China Pharmacist

摘　　要：目的:对我院地高辛血浓度监测结果进行分析,为临床合理应用地高辛提供依据。方法:回顾性分析我院2007年1月～2010年12月1201例次地高辛血浓度监测结果,并分析年龄、性别等对地高辛血浓度的影响。结果:1201例次地高辛血浓度测定值<0.8ng·ml^(-1)的共360例,占29.97%;地高辛血浓度在0.8～2.0ng·ml^(-1)治疗范围内的共611例,占50.87%;地高辛血浓度>2.0ng·ml^(-1)的共230例,占19.15%。性别对地高辛血浓度无显著影响。随年龄增大,地高辛血浓度呈增高的趋势。结论:我院地高辛的应用主要为老年患者,及时监测地高辛血浓度,对制订个体化给药方案,确保临床疗效,减少毒性反应的发生,具有十分重要的意义。Objective：To analyze the monitoring results of serum concentrations of digoxin from the year of 2007 to 2010 in this hospital.Method：The serum concentrations of digoxin were measured by fluorescence polarization immunoassay,and the monitoring results were subjected to statistical analysis.Result：In the total 1 201 cases who were treated with digoxin,the blood drug levels in 360 cases（29.97%）were below 0.8 ng·ml^-1,611 cases（50.87%）between 0.8 and 2.0 ng·ml^-1,and 230 cases（19.15%）above 2.0 ng·ml^-1.Gender had no effect on the blood drug levels,while with the age increase,the serum concentrations were raised accordingly. Conclusion：To ensure clinical efficacy and reduce incidence of toxic reactions,it is very important to monitor the blood drug levels and formulate individual dosage regimen.

关 键 词：地高辛 血药浓度监测 合理用药 

分 类 号：R97[医药卫生—药品]