Crystal structure and DNA binding studies of a cobalt(Ⅱ) complex containing mixed-ligands of 1,10-phenathroline and glycollic acid  

作　　者：Hai Bin Lin Qing Xiang Wang Cong Min Zhang Wen Qi Li 

机构地区：[1]Department of Chemistry and Environmental Science,Zhangzhou Normal University,Zhangzhou 363000,China [2]Department of Hai Bin Lin,Qing Xiang Wang,Cong Min Zhang,Wen Qi Li a Department of Chemistry and Environmental Science,Zhangzhou Normal University,Zhangzhou 363000,China b Department of Bioscience with Technique,Zhangzhou Normal University,Zhangzhou 363000,China

出　　处：《Chinese Chemical Letters》2011年第8期969-972,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.20805041);Training Programme Foundation for Excellent Youth Researching Talents of Fujian's Universities(No.JA10201);Key Provincial University Project of Fujian(No.2008F5064);Research Foundation of Fujian Education Department (No.JA09170)

摘　　要：A cobalt（11） complex containing mixed-ligands of 1,10-phenathroline（phen） and glycollic acid（GA）.｜Co（GA）_2（phen）｜ was synthesized and its structure was characterized by X-ray diffraction.The interaction of the complex with DNA was investigated by electronic absorption spectra and electrochemical methods.Electronic absorption spectrum experiments showed that after interaction with DNA.the characteristic absorption peaks of ｜Co（GA）_2（phen）｜ underwent hypochromic effect as well as redshift. Also,the binding strength of 3.8×10~4L/mol was estimated by titration method.Electrochemical assays revealed that the redox peak currents of the complex decreased obviously accompanied by a positive shift of the formal potential after association with DNA.All these results revealed that the synthesized cobalt complex bound with DNA via an intercalation mode.A cobalt（11） complex containing mixed-ligands of 1,10-phenathroline（phen） and glycollic acid（GA）.｜Co（GA）_2（phen）｜ was synthesized and its structure was characterized by X-ray diffraction.The interaction of the complex with DNA was investigated by electronic absorption spectra and electrochemical methods.Electronic absorption spectrum experiments showed that after interaction with DNA.the characteristic absorption peaks of ｜Co（GA）_2（phen）｜ underwent hypochromic effect as well as redshift. Also,the binding strength of 3.8×10~4L/mol was estimated by titration method.Electrochemical assays revealed that the redox peak currents of the complex decreased obviously accompanied by a positive shift of the formal potential after association with DNA.All these results revealed that the synthesized cobalt complex bound with DNA via an intercalation mode.

关 键 词：Cobalt complex DNA binding Electronic absorption spectra ELECTROCHEMISTRY 

分 类 号：O614.121[理学—无机化学] TQ462.8[理学—化学]