2005-2009年贵州省伤寒和副伤寒沙门菌耐药性分析  

Analysis on the drug resistance of Salmonella typhi and Salmonella paratyphi in Guizhou Province

作　　者：游旅[1] 韦小瑜[1] 马青[1] 刘英[1] 田克诚[1] 

机构地区：[1]贵州省疾病预防控制中心,贵阳550004

出　　处：《医学动物防制》2011年第8期687-690,共4页Journal of Medical Pest Control

基　　金：贵州省科技厅项目[黔基合计字(2001)3067号]

摘　　要：目的分析贵州省伤寒和甲型副伤寒沙门菌的耐药状况,为临床用药及防控提供依据。方法采用改良K-B法对伤寒、甲型副伤寒沙门菌株进行药物敏感试验。结果贵州省9个市（州、地）26个县（区）的113株伤寒沙门菌和518株甲型副伤寒沙门菌对10种抗生素进行药物敏感性测定。其中伤寒沙门菌除对C IP不耐药,对其余9种抗生素均有不同程度的耐药,甲副沙门菌仅对CFT、NAL、SMZ有不同程度耐药,耐药率达0.88%~95.95%,个别地区出现了对第三代头孢类药的多重耐药株。结论贵州省伤寒、甲副沙门菌耐药情况已较为严重,尤其是多重耐药菌可能会造成伤寒和甲型副伤寒的流行或暴发。加强耐药性监测,指导临床合理用药,对预防控制伤寒和甲型副伤寒具有重要意义。Objective To analyze the drug resistance of Salmonella typhi and Salmonella paratyphi in Guizhou province and provide evidences for clinical medication and control and prevention the disease.Method Using improved Kirby-Bauer method to carry out drug sensitivity tests to Salmonella typhi and Salmonella paratyphi strains.Results 113 S.typhi strains and 518 S.paratyphi strains in 26 counties and 9 cities were tested for drug sensitivity to 10 kinds of antibiotics.Among them,S.typhi strains had varying degrees of drug resistance to 9 kinds antibiotic,except CIP,paratyphi A strains had drug resistance just to CFT,NAL and SMZ,and drug resistance rate reached amony 0.88% to 95.95%.Multidrug resistant strains which resistance to the third generation cephalosporin were found in some places.Conclusions Drug resistance situation of S.typhi and S.paratyphi A in Guizhou province were very serious,multidrug resistant may cause the disease outbreak or prevalence,so it had important significance to prevention and control the disease by enhancing the monitoring of drug resistance and guiding clinical medication.

关 键 词：伤寒菌 甲型副伤寒菌 耐药性 

分 类 号：R378.23[医药卫生—病原生物学] R378.24[医药卫生—基础医学]