肥胖患者血糖波动的特点  

The feature of glycaemic fluctuation in obese patients

作　　者：彭朝胜[1] 曹悦鞍[1] 刘淑云[1] 夏菁[1] 

机构地区：[1]中国人民解放军海军总医院特需医疗部,北京100048

出　　处：《现代医学》2011年第4期424-426,共3页Modern Medical Journal

摘　　要：目的:探讨单纯肥胖患者全天血糖波动的特点。方法:128例受试者按体重指数(BM I)分为肥胖组(n=88)和对照组(n=40),通过动态血糖监测系统(CGMS)监测两组72 h血糖的波动,并进行对比分析。结果:全天血糖平均值肥胖组大于对照组(P<0.05);肥胖组日内餐后血糖峰值及凌晨血糖谷值较正常组延迟1 h左右;肥胖组全天血糖波动最大幅度、血糖波动系数、平均血糖波动幅度、无感知低血糖发生率明显大于对照组(P<0.01)。结论:肥胖患者体内存在异常的血糖波动,了解这种异常血糖波动可能有助于对肥胖及其并发症的防治。Objective： To investigate the greater details about the blood glucose fluctuation in obese patients. Methods： One hundred twenty eight subjects were divided into obesity group （n = 88） and control group （n =40） according to the body mass index. The fluctuating feature of the 72 hours blood glucose in two groups were compared and analysed by continuous glucose monitoring systems. Results： The 24 hours average glucose level in obesity group was significantly higher （ P 〈 0.05 ） than that of control group ; the postprandial glycemic peak and glycemic nadirs at night were delayed about 1 hour compared with control group;the blood glucose fluctuant coefficient, mean amplitude glycemic excursions and incidence of asymptomatic hypoglycemia were significantly higher （P 〈 0.01 ）. Conclusions ： The earlier glucose metabolism abnormality could be found in obese patients and understanding this abnormal glucose spectrum may help to prevention in obesity and its complications.

关 键 词：肥胖 动态血糖监测 血糖波动 

分 类 号：R589.1[医药卫生—内分泌]