全自动换血法治疗新生儿高胆红素血症对机体内环境的影响  

The influence of exchange transfusion on the internal environment of neonates with hyperhillirubinemia

作　　者：杨建生[1,2] 吴本清[1,2] 李志光[1,2] 

机构地区：[1]暨南大学第二临床医学院 [2]深圳市人民医院新生儿科,深圳518020

出　　处：《中国实用医药》2011年第22期11-12,共2页China Practical Medicine

摘　　要：目的观察全自动换血法治疗新生儿高胆红素血症的效果及对机体内环境的影响。方法对56例高胆红素血症新生儿采用全自动换血疗法,观察换血前后血常规、生化及血胆红素水平的变化。结果换血后血总胆红素和间接胆红素均较换血前显著降低(P<0.01),总胆红素换出率为49.7%。换血后血钙、血白细胞、血小板明显下降(P<0.01或P<0.05),但血红蛋白、血糖较换血前明显升高(P<0.01或P<0.05),换血前后血钾、血钠及pH值比较,差异无统计学意义(P>0.05)。结论全自动换血法治疗新生儿高胆红素血症安全有效,对机体内环境有一定影响,但这些影响不对新生儿构成生命危险。Objective To observe the therapeutic effects of exchange transfusion in the treatment of neonates with hyperhillirubinemia and its influence on internal environment.Methods 56 neonates with hyperhillirubinemia received exchange transfusion,the blood routine,biochemistry and levels of serum bilirubin were detected before and after the exchange transfusion.Results After exchange transfusion,the levels of total bilirubin and indirect bilirubin decreased significantly（P0.01）,blood calcium,WBC and platelet count decreased significantly（P0.01 or P0.05）,but Hb and serum glucose increased significantly（P0.01 or P0.05）.No significant difference of serum kalium,natrium and pH was observed before and after the exchange transfusion（P0.05）.Conclusion Exchange transfusion for neonates with hyperhillirubinemia is safe and effective,which has a mild side effect on internal environment homeostasis.

关 键 词：换血疗法 新生儿 高胆红素血症 内环境 

分 类 号：R722.1[医药卫生—儿科]