弱激光通过激活Src增强巨噬细胞吞噬功能  

Low-power Laser Irradiation Enhance Macrophage Phagocytic Capacity through Src Activation

作　　者：周非凡[1] 陆翠霞[1] 邢达[1] 

机构地区：[1]华南师范大学生物光子学研究院激光生命科学研究所,暨激光生命科学教育部重点实验室,广东广州510631

出　　处：《激光生物学报》2011年第4期444-447,共4页Acta Laser Biology Sinica

基　　金：科技部国家重点基础研究973计划项目(2011CB910402;2010CB732602);教育部"长江学者与创新团队计划"创新团队项目(IRT0829);国家自然科学基金项目(30870676;30870658)资助

摘　　要：巨噬细胞对病原菌的吞噬以及随后的降解在机体免疫防御中起重要作用。近年来,对增强巨噬细胞吞噬能力的研究越来越被重视。弱激光具有独特的生物组织学作用特征,从而调节机体多种功能本文重点探讨了He-Ne激光(632.8 nm)照射对巨噬细胞吞噬功能的影响及分子信号调控机理。实验结果表明,弱激光能够通过激活巨噬细胞内Src激酶增强巨噬细胞的吞噬能力。Phagocytosis and subsequent degradation of pathogens by macrophages play a pivotal role in host innate im- munity in mammals. Laser irradiation has been found to produce photobiological effects with evidence of interference with organic functions, In this study, we focused our attention on the effects of He-Ne laser on the phagocytic activity of mac- rophages, the regulation mechanism of phagocytosis was also discussed. Our results indicated that Low-power laser irra- diation can enhance the phagocytosis of macrophage through activation of Src.

关 键 词：弱激光 巨噬细胞 吞噬 SRC 

分 类 号：R312[医药卫生—基础医学] R454.2