nCPAP治疗对糖耐量异常合并睡眠呼吸暂停综合征孕妇糖代谢的影响  

nCPAP therapy on glucose metabolism in IGT with sleep apnea syndrome pregnant women

作　　者：施志敏[1] 李涛平[1] 

机构地区：[1]南方医科大学南方医院睡眠中心,广州市510515

出　　处：《实用医学杂志》2011年第18期3304-3305,共2页The Journal of Practical Medicine

基　　金：国家自然科学基金(编号:30471720);广东省自然科学基金(编号:04020458)

摘　　要：目的:持续气道正压通气(nasal continuous positive airway pressure,nCPCP)对诊断为妊娠期糖耐量异常合并睡眠呼吸暂停的孕妇糖代谢的影响,进一步探讨睡眠呼吸暂停低通气综合征与妊娠期糖耐量异常的相关性及其可能的发病机制。方法:nCPAP治疗妊娠期糖耐量异常合并睡眠呼吸暂停的孕妇15例,治疗前后分别测空腹血糖FBG、胰岛素FINS。结果:12例孕妇顺利完成该研究。FBG、FINS治疗前后均无统计学意义,AHI、LSPO2、HOMA-IR治疗前后有统计学意义。结论:治疗后妊娠期糖耐量异常合并睡眠呼吸暂停的孕妇AHI及LSpO2在治疗期间恢复正常,而且胰岛素敏感性改善。Objective Continuous positive airway pressure therapy on glucose metabolism in IGT pregnant with sleep apnea syndrome women. Methods Through continuous positive airway pressure treatment of 15 IGT with sleep apnea syndrome pregnant women 1 week, fasting blood glucose, FINS were measured before and after treatment, respectively. Results 12 subjects successfully completed the study. Before and after CPAP. FBG, FINS were not statistically significant,before and after treatment, AHI,LSPO2,HOMA-IR were statistically significant. Conclusions After treatment, AHI and LSpO2 returned to normal condition, and insulin sensitivity improved, further support for OSA is a risk factor for development of gestational impaired glucose tolerance.

关 键 词：睡眠呼吸暂停综合征 妊娠期糖耐量异常 持续气道正压通气 

分 类 号：R714.25[医药卫生—妇产科学]