离子液体中Yb(OTf)_3催化下喹唑啉酮衍生物的绿色合成  

Green Synthesis of 2-Arylquinazolin-4(1H)-one Derivatives Catalyzed by Yb(OTf)_3 in Ionic Liquids

作　　者：王树良[1] 杨科[1] 王香善[1] 

机构地区：[1]徐州师范大学化学化工学院江苏省药用植物生物技术重点实验室,徐州221116

出　　处：《有机化学》2011年第8期1235-1239,共5页Chinese Journal of Organic Chemistry

基　　金：江苏省高校自然科学基金(No.08KJD150019);江苏省"青蓝工程"创新团队(No.08QLT001)资助项目

摘　　要：以邻氨基苯甲酰胺和芳醛为原料,离子液体[BMIm]Br为溶剂,Yb(OTf)3为催化剂室温下合成了一系列的2-芳基-2,3-二氢化喹唑啉-4-(1H)-酮衍生物.和其他方法相比,该方法具有反应条件温和、产率高(85%～96%)、环境友好等优点.产物的结构通过熔点,IR,1H NMR和高分辨质谱分析确证.A series of 2,3-dihydro-2-arylquinazolin-4（1//）-one derivatives were synthesized by the reaction of 2-aminobenzamide with aromatic aldehyde at room temperature catalyzed by Yb（OTf）3 in ionic liquid of [BMIm]Br. Compared to the other methods, this method has the advantages of milder reaction conditions, higher yields （85%~96%） and environmental benignity. The structures of the products were characterized by melting points, IR, 1H NMR and HRMS techniques.

关 键 词：喹唑啉-4-(1H)-酮 离子液体 Yb(OTf)3 合成 

分 类 号：O626[理学—有机化学]