微波促进下无溶剂一锅法合成含氟喹唑啉-4(3H)-酮类化合物  

One-Pot Preparation of Fluorinated 4(3H)-Quinazolinones under Microwave Irradiation and Solvent-Free Conditions

作　　者：商文丽[1] 章建民[1] 金见安[1] 陈晓蕾[1] 

机构地区：[1]上海大学理学院化学系上海200444

出　　处：《有机化学》2011年第8期1272-1276,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20972092)资助项目

摘　　要：采用邻胺基苯甲酸、原甲酸三乙酯及含氟苯胺为原料,在微波促进下,无溶剂一锅法高效合成了系列3-氟苯基-喹唑啉-4(3H)-酮类化合物,同时测试了新化合物的荧光性能,并与不含氟同类化合物的荧光发射光谱进行了比较.A facile one-pot method has been developed for the synthesis of fluorine-containing 4（3H）-quinazolinones by a three-component coupling of anthranilic acid, triethyl orthoformate and fluorinated anilines under microwave irradiation and solvent-free conditions. All new compounds are fully characterized by spectral methods, especially, fluorescence.

关 键 词：含氟喹唑啉酮 微波促进 一锅法 无溶剂法 荧光发射光谱 

分 类 号：O626.2[理学—有机化学]