无溶剂条件下新型功能离子液体催化活性亚甲基化合物与查尔酮的Michael加成研究  

Michael Addition of Methylene Active Compounds to Chalcones with Novel Task-specific Ionic Liquids as Catalysts under Solvent-free Conditions

作　　者：应安国[1] 郑人华[1] 武承林[1] 梁华定[1] 葛昌华[1] 蒋华江[1] 

机构地区：[1]台州学院医药化工学院台州317000

出　　处：《有机化学》2011年第8期1312-1318,共7页Chinese Journal of Organic Chemistry

基　　金：台州学院培育基金(No.2011PY23)资助项目

摘　　要：以基于DBU(1,8-diazabicyclo[5.4.0]undec-7-ene)的新型功能离子液体[DBU][Ac],[DBU][Lac],[DBU][Tfa],[DBU][n-Pr]和[DBU][n-Bu]为催化剂,研究了无溶剂条件下活性亚甲基化合物与查尔酮的Michael加成反应.反应时间短、收率高、后处理简单、离子液体重复使用6次而活性未发现明显下降.Michael addition of methylene active compounds to chalcones using DBU （1,8-diazabicyclo- [5.4.0]undec-7-ene）-derived ionic liquids [DBU][Ac], [DBU][Lac], [DBU][Tfa], [DBU][n-Pr] and [DBU][n-Bu] as catalysts under solvent-free conditions was performed. The reactions proceed smoothly with high to excellent yields. The work-up is simple and the ionic liquid [DBU][Ac] could be reused six times without significant loss of catalytic activity.

关 键 词：DBU 功能离子液体 MICHAEL加成 重复使用 

分 类 号：O643.32[理学—物理化学]