乙肝解毒微丸制备工艺研究  

Study on Preparation Technology of Yiganjiedu Pellets

作　　者：尹银华[1] 周洪波[2] 

机构地区：[1]遵义医学院第五附属<珠海>医院药剂科,广东珠海519100 [2]广东药学院中山校区,广东中山528458

出　　处：《中国药业》2011年第16期51-52,共2页China Pharmaceuticals

摘　　要：目的应用挤出-滚圆法制备中药乙肝解毒微丸,研究微丸制备的最佳处方和工艺。方法采用挤出-滚圆法对润湿剂、药料、乙醇的用量进行筛选,最终筛选出最佳用量。结果用挤出-滚圆法制备的乙肝解毒微丸圆整度好,大小均匀,成品收率高。结论通过加入合适的润湿剂,可以采用挤出滚圆法制备乙肝解毒微丸,该工艺稳定、辅料用量少,挥发性有效成分破坏程度小。Objective To prepare the traditional Chinese patent medicine Yiganjiedu Pellets by the extrusion-spheronization method and to study its optimal formulation and technological process.Methods Using the extrusion-spheronization method,the amounts of wetting agent,medicinal materials and ethyl alcohol were screened and their used amounts were finally optimized.Results By the extrusion-spheronization method,the circularity of Yiganjiedu Pellets was good with even size and high product yield.Conclusion Adding appropriate wetting agent,the extrusion-spheronization method may be used to prepare Yiganjiedu Pellets,in which the technology is stable with less amounts of supplementary materials and small destructiveness of the volatile effective components.

关 键 词：乙肝解毒微丸 挤出-滚圆法 制备工艺 

分 类 号：TQ461[化学工程—制药化工]