麻疹患者T淋巴细胞亚群和调节性T淋巴细胞分析  

Expression of T lymphocyte and regulatory T lymphocyte in patients with measles

作　　者：吕秋琼[1] 许文芳[1] 

机构地区：[1]绍兴市第六人民医院检验科,浙江绍兴312000

出　　处：《疾病监测》2011年第7期516-518,共3页Disease Surveillance

摘　　要：目的探讨成年人及儿童麻疹患者急性期与恢复期T淋巴细胞及调节性T淋巴细胞表达水平的变化。方法成年人及儿童麻疹患者各40例,用流式细胞术分别测定各组出疹期和恢复期患者外周血CD3+总T细胞、CD4+辅助性T细胞(Th)、CD8+细胞毒性T细胞(Tc)及CD4+CD2+5调节性T淋巴细胞(Treg)比例。结果成年人麻疹患者出疹期较对照期外周血CD3+总T和CD4+Th表达水平降低,CD4+CD2+5Treg表达水平升高,恢复期CD4+Th升高,CD8+Tc降低,CD4+/CD8+比值升高,CD4+CD2+5Treg降低。儿童麻疹患者出疹期较对照组CD3+总T、CD4+Th降低,恢复期较出疹期CD3+总T表达回升。结论 T淋巴细胞及调节性T淋巴细胞参与成年人及儿童麻疹患者免疫状态的调节,但其表达水平在成年人和儿童中有差异。Objective To understand the changes in T lymphocyte and regulatory T lymphocyte expression in adults and children infected with measles in acute and convalescence periods.Methods Forty adults infected with measles and 40 children infected with measles were selected.The proportions of CD＋3T cell,CD＋4helper T lymphocyte（Th）,CD＋8cytotoxic T lymphocyte（Tc） and CD＋4CD＋25 regulatory T lymphocyte（Treg） in their peripheral blood in acute and convalescence periods were determined with flow cytometry assay.Results In adults,the expression of CD＋3T cells and CD＋4Th declined and the expression of CD＋4CD＋25 Treg increased in acute period compared with control group,while the expression of CD＋4Th increased,the expression of CD＋8Tc declined and CD＋4/CD＋8increased in convalescence period.In children,the expression of CD＋3 T cells and CD＋4Th declined in acute period compared with control group,and CD＋3 T cell increased in convalescence period.Conclusion T lymphocyte and regulatory T lymphocyte take part in the regulation of immune state in adults and children infected with measles,but their expressions differ in two groups.

关 键 词：麻疹 成年人 儿童 T淋巴细胞亚群 CD4+CD25+调节性T淋巴细胞 

分 类 号：R511.1[医药卫生—内科学]