影响盐酸氟西汀抗抑郁疗效的社会心理学因素  

Analysis of main psychosocial factors affecting the efficacy of antidepressant treatment in depression

作　　者：申景进[1] 张亚林[2] 曹玉萍[2] 李文[2] 李龙飞[2] 陈向一[1] 

机构地区：[1]广东医学院附属深圳市南山医院精神卫生科,518052 [2]中南大学附属湘雅二医院精神卫生研究所

出　　处：《神经疾病与精神卫生》2011年第4期337-340,共4页Journal of Neuroscience and Mental Health

摘　　要：目的探讨影响盐酸氟西汀抗抑郁治疗效果相关的社会心理学因素。方法采用盐酸氟西汀20mg／d固定剂量对103例抑郁症患者治疗6周。入组患者根据疗效分为缓解组和未缓解组。采用自行设计的问卷及汉密尔顿抑郁量表（HAMD）对患者社会心理学情况与氟西汀疗效的关系进行量化研究。结果（1）缓解组和未缓解组在性别、发病年龄、民族、受教育年限、是否首发、病程、是否住院治疗及居住状况的差异均无统计学意义（P〉0．05），缓解组已婚患者所占比例显著高于未缓解组（P=0．010）；（2）两组在近3个月内是否发生生活事件、日常体力劳动强度、锻炼身体频度、工作和生活节奏、工作和生活环境噪音及每天平均睡眠时间方面差异均无显著性（P〉0．05）。未缓解组治疗前不饮茶患者所占比例显著少于缓解组（P〈0．01）；而饮茶与阻滞因子基础分显著负相关（P〈0．01）。两组在治疗前吸烟及饮酒方面差异无显著性（P〉0．05）。结论抑郁症疗效与婚姻状况有关，已婚患者可能更易恢复；治疗前习惯饮茶的患者易恢复，可能与阻滞症状轻有关。Objective To investigate the psychosocial factors effecting the efficacy of fluoxetine treatment in depression patients. Methods 103 depression patients were treated with fluoxetine （20mg/ d） for 6 weeks. Patients were classified as remission group and non--remission group according to the response endpoint to fluoxetine treatment. Subjects received standardized clinical assessments,including the demographic data, the psychosoeial data, the Hamilton Depression Rating for Depression. Results （1）There were no significant differences between two groups in gender,age of onset,ethnicity, years of education, number of episode, course of depression, inpatients or outpatients and dwell situation （P 〉 0.05）. The proportion of married patients was significantly higher in remission group than in non--remission group （P = 0. 010）. （2） There were no significant differences between two groups in life events during the past three months, physical laboring intensity, exercise frequency, life pace, surrounding noise level,averaged sleep hours （P 〉 0.05）. Before treatment, the proportion of patients who did no drink tea was significantly lower in non-remission group than in remission group （P 〈0.01）, which had significant positive correlation with fluoxetine efficacy. But the frequency of tea--drinking had a significant negative correlation with baseline scores of retardarce factor. There were no significant differences between two groups of smoking and drinking frequency （P 〉 0.05）. Conclusions Married patients maybe be able to achieve remission more easily. Patients who drinking tea may have better outcome possible because of basline retardarce symptoms.

关 键 词：抑郁症 心理学 社会 治疗结果 影响 

分 类 号：R971.43[医药卫生—药品]