康心复律方对病态窦房节综合征家兔窦房结电生理功能影响  

Effect of Kangxin Fulu Recipe on Electrophysiological Functions of the Sinoatrial Node in Rabbits with Sick Sinus Syndrome

作　　者：刘如秀[1] 王妮娜[1] 李汇博[1] 暴美静[1] 汪艳丽[1] 

机构地区：[1]中国中医科学院广安门医院心内科,北京100053

出　　处：《中国中西医结合杂志》2011年第8期1118-1121,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金资助项目(No.30873332)

摘　　要：目的在建立病态窦房结综合征动物模型的基础上,通过测量反映窦房结电生理功能的各项指标,并用中药康心复律方进行干预,探讨其对病态窦房结综合征家兔窦房结电生理功能的影响。方法大耳白兔60只,随机分为正常组,模型组,阿托品组,康心复律方高、中、低剂量组6组,每组10只。正常组不造模,其余5组均采用甲醛加压注射渗透法建立兔病态窦房结综合征模型,测量各组造模前后及灌胃治疗7天前后AA间期(PP间期)、窦房结传导时间(SACT)、窦房结恢复时间(SNRT)、校正窦房结恢复时间(CSNRT)的变化。结果 (1)康心复律方高、中剂量组与阿托品组均能显著缩短AA间期及SACT(P<0.05,P<0.01),且高、中剂量组优于阿托品组(P<0.05)。(2)康心复律方高剂量组与阿托品组均能缩短SNRT与CSNRT,两组间比较差异无统计学意义(P>0.05)。结论康心复律方治疗病态窦房结综合征的电生理机制可能与其促进窦房结自律性和传导功能的恢复有关。Objective To study the effect of Kangxin Fulu Recipe （KFR） on electrophysiological functions of the sinoatrial node in rabbits with sick sinus syndrome （SSS）.Methods Sixty big ears white rabbits were randomly divided into six groups,i.e.,the normal group,the model group,the atropine group,the high dose KFR group,the middle dose KFR group,and the low dose KFR group,ten in each group.SSS model was established by injecting formaldehyde to the sinoatrial node except those in the normal group.Changes in AA interval,the sinoatrial conduction time （SACT）,the sinus node recovery time （SNRT）,and the corrected sinus node recovery time （CSNRT） were measured before and after modeling,seven days before and after gastrogavage.Results （1） The AA interval and SACT could be significantly shortened in the high dose KFR group,the middle-dose KFR group,and the atropine group （P0.05,P0.01）.Better effects were obtained in the former two groups （P0.05）.（2） SNRT and CSNRT could be shortened in the high dose KFR group and the atropine group,with no statistical difference between the two groups （P0.05）.Conclusion The electrophysiological mechanism of KFR might possibly be correlated with accelerating the recovery of sinus node autorhythmicity and conduction functions.

关 键 词：康心复律方 病态窦房结综合征模型 电生理 

分 类 号：R541.7[医药卫生—心血管疾病]