妊娠相关蛋白A在急性冠状动脉综合征诊断中的应用分析  

Application of Pregnancy-Associated Plasma Protein A for the Diagnosis of Acute Coronary Syndrome

作　　者：曾昭伟[1] 李会强[1] 吴金丹 谈志龙 张连祥[3] 王学谦[4] 

机构地区：[1]天津医科大学,300070 [2]沃克(天津)生物科技有限公司 [3]天津市胸科医院检验科 [4]天津市天津医院

出　　处：《天津医药》2011年第9期785-787,共3页Tianjin Medical Journal

基　　金：天津市科技计划项目(项目编号:08ZCGYSF01800)

摘　　要：目的:探讨妊娠相关蛋白A(PAPP-A)在冠状动脉综合征(ACS)诊断中的临床价值。方法:收集2010年5月—2010年7月收治的ACS患者(ACS组)117例和稳定型心绞痛患者(SAP组)68例,正常组84例为健康体检者。采用酶联免疫检测(ELISA)分析其PAPP-A水平。跟踪ACS、SAP患者治疗3周后血清PAPP-A水平变化。结果:PAPP-A在ACS患者血清中水平最高,与SAP患者和正常组比较差异有统计学意义(均P<0.001),而SAP患者和正常组差异无统计学意义(P=0.641)。与治疗前比较,治疗3周后ACS患者PAPP-A变化差异有统计学意义(t=23.105,P<0.01),而SAP患者差异无统计学意义(t=1.031,P>0.05)。结论:PAPP-A和斑块不稳定性有关,其水平检测有助于预测急性冠脉事件发生、危险程度以及康复情况。Objective： To investigate clinical values of pregnancy-associated plasma protein A （PAPP-A） in the detection of acute coronary syndrome （ACS）. Methods： One hundred and seventeen samples of ACS patients were collected between May 2010 to July 2010, including 68 samples of stable angina pectoris （SAP） and 84 samples of normal individuals. The level of PAPP-A was detected by ELISA immunoassay in samples of two groups. The serum values of PAPP-A were detected after 3 weeks treatment in ACS and SAP patients. Results： It was found that the serum level of PAPP-A was the highest in ACS patients, which was significantly different compared with those of SAP and normal controls （P 0.001）. But, there was no significant difference in serum level of PAPP-A between SAP and normal controls （P = 0.641）. The serum level of PAPP-A was significantly different before and after 3-week treatment in ACS patients （t = 23.105, P 0.01）. However, no significant difference was found in SAP patients （t = 1.031, P 0.05）. Conclusion： The serum level of PAPP-A was related with the instability of atherosclerotic plaques. The detection of serum level of PAPP-A is helpful to predict the occurrence, the level of risk and rehabilitation status of acute coronary events.

关 键 词：妊娠相关血浆蛋白A 急性冠状动脉综合征 动脉粥样硬化 心绞痛 酶联免疫吸附测定 试剂盒 诊断 

分 类 号：R543.3[医药卫生—心血管疾病]