铜绿假单胞菌联合滑石粉治疗恶性胸腔积液临床观察  

Clinical Observation of PA-MSHA Combined with Talcum Powder in the Treatment of Malignant Pleural Effusion

作　　者：黄崇标[1] 崔焱[1] 辛亮[1] 杨彦卓[1] 齐大亮[1] 

机构地区：[1]天津市肿瘤防治重点实验室,天津医科大学附属肿瘤医院高级病房,300060

出　　处：《天津医药》2011年第9期797-799,共3页Tianjin Medical Journal

摘　　要：目的:观察铜绿假单胞菌制剂联合滑石粉治疗恶性胸腔积液的疗效。方法:74例恶性胸腔积液患者经皮穿刺置管彻底引流胸腔积液,随机分成3组,治疗组28例,为铜绿假单胞菌联合滑石粉治疗组;对照组A共26例,为滑石粉对照组;对照组B共20例,为铜绿假单胞菌对照组。将滑石粉或铜绿假单胞菌制剂溶于生理盐水,经胸腔置管于胸腔内注射,每周1次,连用1～3周。1个月复查,比较3组的总有效率及发热、胸痛等不良反应发生率。结果:治疗组总有效率高于2个对照组(χ2分别为6.273和4.255,均P<0.05)。3组均未发生严重并发症,治疗组及对照组B患者接受干预后白细胞数较对照组A高(P<0.01);对照组B发生胸痛比例较治疗组及对照组A低(P<0.05);治疗组和对照组中度以上发热比例差异无统计学意义(P>0.05)。结论:铜绿假单胞菌联合滑石粉治疗恶性胸腔积液是一种安全有效的治疗方法。Objective：To prospectively study the clinical efficacy of combined administration of pseudomonas aeruginosa-mannose sensitive hemagglutinin（PA-MSHA） and talcum powder in the treatment of malignant pleural effusion.Methods：Seventy-four patients suffered from malignant pleural effusion were randomly divided into three groups,observation group（n=28）,talcum powder group（A group,n=26） and PA-MSHA group（B group,n=20）.Patients in the observation group were given combined treatment of PA-MSHA and talcum powder.All the patients received thoracic close drainage by central vein catheterization set.The medicine was then injected into thoracic cavity through the catheter,weekly administration for 1-3 weeks depending on the clinical efficacy.The total effective rate and symptoms of fever,chest pain and other adverse reactions were compared in patients of three groups.Results：The total effective rate was higher in treatment group than that of control group（P 0.05）.No serious side effects were found in three groups.The level of white cell count was higher in observation group and B group than that of A group（P 0.01）.There were fewer symptoms of chest pain in group B than that of observation group and group A（P 0.05）.There was no significant difference in moderate fever between three groups.Conclusion：Combined administration of PA-MSHA and talcum powder through thoracic drainage catheter proved to be a safe and effective method.

关 键 词：假单胞菌 铜绿 胸腔积液 恶性 滑石粉 胸膜固定术 治疗 

分 类 号：R979.5[医药卫生—药品]