高嗜酸细胞综合征的分类研究进展  

Progress in Classification of Hypereosinophilic Syndrome——Review

作　　者：安志明[1] 翟勇平[1] 

机构地区：[1]南京军区南京总医院血液病科,江苏南京210002

出　　处：《中国实验血液学杂志》2011年第4期1087-1091,共5页Journal of Experimental Hematology

摘　　要：高嗜酸细胞综合征(hypereosinophilic syndrome,HES)是一组少见的异质性疾病,以外周血嗜酸细胞明显增多和靶器官功能损害为特点,其不同亚型拥有不同的病因、发病机制和治疗方法。以往HES的预后非常差,近年来随着科学技术和医疗水平的发展,HES的分类、诊断和治疗等方面都有了显著进步,包括一些新的靶向治疗药物,如酪氨酸激酶抑制剂和人源性单克隆抗体,增加了HES治疗药物的选择,但同时又增添临床用药的复杂性。本文将主要讨论HES的分类及其各亚型的特点(包括治疗),以帮助临床医生更好的理解HES。Hypereosinophilic syndromes （HES） are a heterogeneous group of uncommon disorders which characterized by marked peripheral eosinophilia and function damage of target organ, with different etiologies, mechanisms and therapies in different subtypes. Formerly the prognosis was very poor, nowadays with great development in science and medicine, we can understand lIES much better in classification, diagnosis and therapy, including the development of novel targeted therapies, such as tyrosine kinase inhibitors and humanized monoclonal antibodies, which increased the treatment selection and complexity of therapeutic decisions in lIES. This review discusses the classification of HES and characters of different subtypes, including therapeutic methods, which can help clinical doctors to have a good understanding of HES.

关 键 词：高嗜酸细胞综合征 嗜酸细胞 酪氨酸激酶抑制剂 

分 类 号：R557.5[医药卫生—血液循环系统疾病]