尿胱抑素C评估腹腔镜气腹肾脏影响的价值  

Significance of urinary cystatin C detection in evaluating the effect of CO_2 pneumoperitoneum on the kidney

作　　者：卜珊珊[1] 尹忠诚[1] 李红梅[1] 李胜开[1] 张颖[1] 

机构地区：[1]徐州医学院附属医院肾脏病科,221000

出　　处：《江苏医药》2011年第16期1907-1909,共3页Jiangsu Medical Journal

基　　金：江苏省卫生厅医学科技发展基金(H200833)

摘　　要：目的通过检测尿胱抑素C(UCysC)水平,预测腹腔镜气腹对肾脏的影响。方法留取20例腹腔镜手术患者(腹腔镜组)及16例传统开腹手术患者(对照组)术前及术后不同时间点血液及尿液标本,测定肾功能及尿UCysC及尿肌酐(UCr)水平。结果两组患者均无急性肾损伤。与术前相比,腹腔镜组术后6hUCysC水平有所升高(P<0.05),2h和6h的UCysC/UCr比值显著升高(P<0.05);对照组各时间点UCysC水平及各时间点UCysC/UCr比值差异无统计学意义。结论腹腔镜CO2气腹术后UCysC水平和UCysC/UCr比值短暂升高可提示肾小管短暂损伤。Objective To study the value of urinary cystatin C（UCysC） detection in early predicting renal injury induced by CO2 pneumoperitoneum.Methods Renal function,UCysC and urinary creatinine（UCr） were examined in 20 patients（group A） undergoing laparoscopic procedures and 16 cases（group B） undergoing conventional open abdominal surgeries before and at 2,6 and 12 h after operation.Results No acute renal injury was seen in both groups.Compared to before,UCysC was increased at 6 h after operation（P0.05） and the ratio of UCysC to UCr was increased at 2 h and 6 h after operation（P0.05）,which were not in group B.Conclusion The transient increase of UCysC and the ratio of UCysC to Ucr may indicate the laparoscopic surgery-induced renal tubular injury.

关 键 词：胱抑素C CO2气腹 急性肾损伤 

分 类 号：R657[医药卫生—外科学]