线粒体生物合成相关基因在子痫前期患者胎盘组织中的表达及意义  

Expression and significance of mitochondrial biogenesis-related genes in preeclampsia

作　　者：苏琳[1] 王小青[1] 张翔[1] 

机构地区：[1]南京医科大学附属南京妇幼保健院产科,210004

出　　处：《江苏医药》2011年第16期1925-1928,共4页Jiangsu Medical Journal

基　　金：南京市医学科技发展资助项目(ZKM05042)

摘　　要：目的探讨线粒体生物合成相关基因PGC-1α、PGC-1β、NRF1、NRF2和ERRαmRNA在子痫前期(PE)患者胎盘组织中的表达与意义。方法采用RT-PCR技术测定36例正常足月妊娠妇女(A组)和24例轻度PE患者(B组)及17例重度PE患者(C组)胎盘组织中PGC-1α、PGC-1β、NRF1、NRF2和ERRαmRNA表达水平。结果 C组PGC-1α、PGC-1β、NRF1、NRF2和ERRαmRNA表达水平分别为0.43±0.13、0.20±0.09、0.29±0.13、0.71±0.14和0.48±0.13,B组分别为0.78±0.13、0.37±0.10、0.96±0.19、0.81±0.22和1.08±0.16,均显著低于A组的1.47±0.19、0.80±0.14、1.84±0.22、1.59±0.18和1.54±0.21(P<0.05)。C组PGC-1α、PGC-1β、NRF1和ERRαmRNA表达水平显著低于B组(P<0.05)。结论上述线粒体生物合成相关基因在PE患者胎盘组织中的差异表达参与了PE的病理生理过程。Objective To investigate the expression and significance of mitochondrial biogenesis-related genes PGC-1α,PGC-1β,NRF1,NRF2 and ERRα mRNA in the preeclampsia.Methods The expression levels of PGC-1α,PGC-1β,NRF1,NRF2 and ERRα mRNA in the placenta of 36 healthy term pregnant women（group A）,24 patients with mild preeclampsia（group B） and 17 patients severe preeclampsia（group C） were detecded by RT-PCR.Results The expression levels of PGC-1α,PGC-1β,NRF1,NRF2 and ERRα mRNA were 0.43±0.13,0.20±0.09,0.29±0.13,0.71±0.14 and 0.48±0.13 in group C and 0.78±0.13,0.37±0.10,0.96±0.19,0.81±0.22 and 1.08±0.16 in group B,respectively,which were all significantly lower than 1.47±0.19,0.80±0.14,1.84±0.22,1.59±0.18 and 1.54±0.21 in group A（P0.05）.The expressions of PGC-1α,PGC-1β,NRF1 and ERRα mRNA in group C were significantly lower than those in group B（P0.05）.ConclusionThe differential expression of mitochondrial biogenesis-related genes above in preeclampsia placenta play an important role in the physiological and pathological process of preeclampsia.

关 键 词：PGC-1Α PGC-1β NRF1 NRF2 ERRα 子痫前期 胎盘 

分 类 号：R714[医药卫生—妇产科学]