CpG ODN对破骨细胞分化调控作用的研究进展  

The Current Studies about the Regulation Effect of CpG Oligodeoxynucleotides on Osteoclast Differentiation

作　　者：王静[1] 侯旭[1] 孙新华[1] 

机构地区：[1]吉林大学口腔医院正畸科,吉林长春130021

出　　处：《现代生物医学进展》2011年第17期3390-3392,共3页Progress in Modern Biomedicine

基　　金：吉林省自然科学基金(201015203)

摘　　要：CpG ODN(CpG oligodeoxynucleotides)是一类可模拟细菌DNA免疫活性效应的寡脱氧核苷酸,其生物学功能受自身结构特征影响。特定序列的CpG ODN可通过与破骨细胞前体、前破骨细胞、成骨细胞表面的TLR9结合,调节RANKL、M-CSF、TNF-a、IL-12、TREM-2等细胞因子的表达水平,促进或抑制破骨细胞的形成与分化。本文就CpG ODN对破骨细胞(osteoclast,OC)分化调控作用的研究进展加以综述。CpG ODN is a kind of oligodeoxynucleotides which simulate the immune activity effect of bacterial DNA. Its biological function is decided by its structure characteristics.Specific CpG ODN can stimulate or inhibit the osteoelastogenesis via the toil-like receptors 9 of OC precursors ,pre-osteoclasts and Osteoblasts by adjusting the level of RANKL, M-CSF, TNF-α, II,-12, TREM-2. The paper reviews introduces current studies about CpG oligodeoxynucleotides and its regulation effect on osteoclast differentiation.

关 键 词：CPG寡脱氧核苷酸 破骨细胞 分化 TOLL样受体9 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]