不同月龄婴儿巨细胞病毒感染临床特点  

Clinical manifestations of infant cytomegalovirns infection in different age

作　　者：崔曙东[1] 陈吉庆[1] 胡毓华[1] 邵小松[1] 章晔[1] 

机构地区：[1]南京医科大学第一附属医院儿科,210029

出　　处：《中国医师进修杂志》2011年第24期15-17,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨不同月龄婴儿巨细胞病毒感染的临床特点。方法回顾性分析237例巨细胞病毒感染婴儿的临床资料，按月龄分成三组：0．3个月为A组（77例）、4～6个月为B组（65例）和7～12个月为C组（95例）。结果呼吸道感染在三组中比率最高；A组伴有气喘的呼吸道感染者明显小于其他两组[24．7％（19／77）比61．5％（40／65）、61．1％（58／95）]（P〈0．01）；随着月龄增长，黄疸的比率逐渐减低[23．4％（18／77）→7．7％（5／65）→1．1％（1／95）]（P〈0．05）；三组腹泻、出血比较差异无统计学意义（P〉0．05）。在三组中丙氨酸氨基转移酶及天冬氨酸氨基转移酶升高率相似；A组γ-谷氨酰转移酶（GGT）升高率达77．9％（60厂77），明显高于其他两组[10．8％（7，65）、2．1％（2／95）]（P〈0．01）；B组粒细胞减少较其他两组更明显（P〈0．05），C组更易发生贫血（P〈0．05）。结论不同月龄婴儿巨细胞病毒感染各具不同的临床特点。Objective To explore the clinical manifestations of infant cytomegalovirus infection in different age. Method The clinical data of 237 infants who suffered from cytomegalovirus infection was analyzed retrospectively and divided into three groups ： 0-3 months old （77 cases, group A）, 4-6 months old （65 cases, group B ）, 7-12 months old （95 cases, group C ）. Results The incidence of respiratory infection was the highest among all infectious organs in three groups, the numbers of patients who had wheeze in group A was less than that in the other two groups [ 24.7 % （ 19/77 ） vs. 61.5 % （ 40/65 ）, 61.1% （ 58/95 ） ] （ P 〈 0.01 ）. The incidence of jaundice decreased gradually as the babies grew up [ 23.4%（ 18n7 ）→7.7%（5/65 ）→1.1% （ 1/95 ） ] （p 〈 0.05 ）. There was no significant difference in diarrhoea and bleeding among three groups （P 〉 0.05 ）. The proportion of alanine aminotransferase ], aspartate amino transferase increasing was similar among three groups, but gamma-glutamyl transferase （GGT） was different, the proportion of GGT increasing was 77.9% （ 60/77 ） in group A which was higher than that in the other two groups [ 10.8% （ 7/65 ）, 2.1% （ 2/95 ） ]. Granulocytopenia in group B was obviously decreased compared with the other two groups（P 〈 0.05 ）, anemia was easily occurred in group C （P 〈 0.05）. Conclusion The injury of cytomegalovirus infection may be related to month old.

关 键 词：婴儿 巨细胞病毒 临床表现 

分 类 号：R72[医药卫生—儿科]