COPD患者痰IL-8及TNF-α水平变化及其临床应用价值  

The Changes of Sputum IL-8 and TNF-α Levels in COPD Patients and Their Clinical Value

作　　者：卓连坤[1] 王小丽[2] 张凤[2] 周晓[1] 

机构地区：[1]山东省莱芜市人民医院核医学科,山东莱芜271100 [2]山东省莱芜市人民医院检验科,山东莱芜271100

出　　处：《标记免疫分析与临床》2011年第4期217-219,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：通过动态检测慢性阻塞性肺疾病(COPD)患者不同时期痰中IL-8及TNF-α的水平变化,探讨痰IL-8及TNF-α水平变化在COPD诊疗中的应用价值。对58例COPD患者治疗过程中不同时段血清及痰标本,用RIA法测IL-8及TNF-α水平。结果显示,COPD急性加重期患者痰中IL-8及TNF-α水平明显高于稳定期,与血清中IL-8及TNF-α水平变化相一致。痰标本中的IL-8及TNF-α水平升高及降低均早于血清中水平变化。结论:COPD患者痰IL-8及TNF-α水平变化较血清中水平变化在临床诊疗及预后判断中价值更大。To investigate the changes and role of interleukin-8（IL-8）and tumor necrosis factor-α（TNF-α） in the diagnosis and therapy of COPD,the levels of IL-8 and TNF-α in serum and sputum samples in 58 COPD cases during different therapy periods were detected by radioimmunoassay.The results showed that the sputum IL-8 and TNF-α levels in COPD patients at the attack aggressive stage were significantly higher than those in the stable stage,which were in accord with those changes in serum samples.Furthermore,the changes of IL-8 and TNF-α levels in sputum samples were earlier than the changes in serum samples.The changes of sputum IL-8 and TNF-α levels in COPD patients may play a more important role than the changes of serum samples in the diagnosis and prognosis of patients with COPD.

关 键 词：慢性阻塞性肺疾病 白细胞介素-8 肿瘤坏死因子-Α 临床应用 

分 类 号：R563.9[医药卫生—呼吸系统]