冠心病患者CGA、NT-proBNP和Hs-CRP水平变化及临床应用分析  

Changes of CGA,NT-proBNP and Hs-CRP Levels in Patients with Coronary Heart Disease and Their Clinical Significance

作　　者：杜同信[1] 王自正[1] 蔡娟 叶飞 

机构地区：[1]南京医科大学附属南京第一医院南京临床核医学中心 [2]南京市心血管病医院,江苏南京210006

出　　处：《标记免疫分析与临床》2011年第4期227-229,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：探讨血清CGA、NT-proBNP、Hs-CRP水平和冠心病发病机制及不稳定性心绞痛(UAP)治疗前后与其相关性;用CL-ELISA及RIA法测定冠心病组和UAP经皮冠状动脉形成术(PTCA)治疗前后及对照组血清CGA、NT-proBNP和Hs-CRP水平并进行分析。结果表明冠心病组NT-proBNP水平与对照组比较有显著性差异(P<0.01),AMI组和UAP组比SAP组升高更明显;Hs-CRP水平比对照组明显增高(P<0.05),特别是UAP组和AMI组升高明显(P<0.001);AMI组血清CGA水平明显高于对照组和其它两组;CGA、NT-proBNP、Hs-CRP三项在UAP组治疗前后比较显著性差异(P<0.05);CGA、NT-proBNP、Hs-CRP参与冠心病的发病过程,可预测AMI远期心功能的恢复,UAP组经PTCA支架术后三项指标均明显降低,为疗效观察提供参数。To explore the correlations between the changes of CGA,NT-proBNP and Hs-CRP levels in patients with coronary heart disease（CHD） and the pathogenesis concerning of CHD and unstable angina pectoris（UAP） before and after percutaneous transluminal coronary angioplasty（PTCA）.The levels of CGA,NT-proBNP and Hs-CRP in 210 patients with CHD,65 UAP patients before and after PTCA,and 30 healthy controls were detected by Chemiluminescence-ELISA and RIA.The result showed that the NT-proBNP levels in CHD group were much higher than that in healthy controls（P0.01）,especially in AMI and UAP groups comparing to stable angina pectoris（SAP） group.There was significantly increase of the HsCRP levels in CHD group comparecl with heatthy gronp（P0.05）,especially in UAP and AMI groups（P0.001）.The CGA levels in AMI group were much higher than that of in healthy,UAP and SAP groups.The CGA,NT-proBNP and Hs-CRP levels were significantly decreased after PTCA treatment in UAP group（P0.05）.The CGA,NT-proBNP and Hs-CRP were involved in pathogenesis of CHD,and were prognostic indicator concerning of long-term heart function.The CGA,NT-proBNP and Hs-CRP levels in patients with UAP decrease after PTCA treatment,and may be acted as a useful parameter to monitor treatment effect.

关 键 词：冠心病 嗜铬粒蛋白A 脑钠肽 高敏C-反应蛋白 CL-ELISA RIA 

分 类 号：R446.6[医药卫生—诊断学] R541.4[医药卫生—临床医学]