绝经后妇女骨质疏松症患者血清β-Crosslaps、PINP和N-MID检测的评价  

Clinical Value of Detection of Serum β-Crosslaps,PINP and N-MID in Postmenopausal Women with Osteoporosis

作　　者：欧萌萌[1] 黄建荣[2] 

机构地区：[1]南京医科大学附属无锡市精神卫生中心检验科,江苏无锡214151 [2]无锡市人民医院检验科,江苏无锡214023

出　　处：《标记免疫分析与临床》2011年第4期238-240,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：评价绝经后妇女骨质疏松症患者血清β胶原特殊序列(β-Crosslaps)、总骨I型前胶原氨基酸延长链(PINP)、骨钙素(N-MID)浓度变化的意义。对116例绝经后妇女用双能X线骨密度仪分为无骨质疏松组(NOP组)51例,有骨质疏松症组(OP组)65例,测定三种血清骨标志物水平。结果表明:绝经后妇女OP组血清β-Crosslaps、PINP和N-MID浓度明显高于NOP组,绝经后妇女高于绝经前,且差异均有统计学意义(P<0.01)。绝经后妇女三种血清骨标志物与骨质疏松存在密切的相关性,骨标志物与骨密度的联合检测对诊断绝经后妇女骨质疏松症具有一定临床意义。To evaluate the clinical value of detection of concentration of β-Crosslaps,PINP and N-MID in postmenopausal women with osteoporosis,116 postmenopausal women were detected by dual X-ray absorptionmetry and divided into NOP group（51 cases） and OP group（65 cases）.The serum levels of three bone markers（β-Crosslaps,PINP and N-MID） were measured.The results showed that serum levels of β-Crosslaps,PINP and N-MID in OP group were significantly higher than that in NOP group（P0.01）.It was suggested that three bone markers level might be closely related with osteoporosis in postmenopausal women.The combined detection of bone markers and bone mineral density has important clinical value in the diagnosis of osteoporosis in postmenopausal women.

关 键 词：骨标志物 β胶原特殊序列 总骨I型前胶原氨基酸延长链 骨钙素 绝经后 骨质疏松 骨密度 妇女 

分 类 号：R580[医药卫生—内分泌]