毛细支气管炎与白三烯受体拮抗剂  

Bronchiolitis and Leukotriene Receptor Antagonist

作　　者：马晓晖[1] 崔振泽[1] 黄燕[1] 

机构地区：[1]大连市儿童医院呼吸内科,辽宁大连116012

出　　处：《医学综述》2011年第15期2249-2252,共4页Medical Recapitulate

摘　　要：毛细支气管炎是婴幼儿常见的下呼吸道感染性疾病,病毒感染是主要致病原因。毛细支气管炎的病理、生理变化与哮喘有许多相同之处,许多炎性介质参与其中,造成呼吸道高反应,诱发喘息。在这些炎性介质中,白三烯在毛细支气管炎呼吸道炎症的发生中起到重要作用,而白三烯受体拮抗剂在毛细支气管炎的治疗中取得较好疗效。现就白三烯受体拮抗剂的作用机制及其在毛细支气管炎中的临床研究进行综述,探讨毛细支气管炎的治疗及早期干预以及降低喘息复发率的有效方法。Bronchiolitis is the most common lower respiratory tract infection in infants,the major cause of which is virus infection.Studies have indicated that there are many similarities in pathophysiology between bronchiolitis and asthma,and there are many inflammatory mediators involved,which result in airway hyperresponsiveness,and lead to wheeze.Among the inflammatory mediators,leukotriene plays an important role in bronchiolitis airway inflammation,so leukotriene receptor antagonist is an effective treatment for bronchiolitis.Here is to review the mechanism of leukotriene receptor antagonist and its clinical studies in bronchiolitis,in order to disclose a better treatment and effective early intervention method of bronchiolitis,and to cut down the relapse rate of wheezing.

关 键 词：毛细支气管炎 白三烯 白三烯受体拮抗剂 

分 类 号：R725[医药卫生—儿科]