血清中胎盘生长因子水平变化与子痫前期的关系研究  

Study of the Relationship between Preeclampsia and Placenta Growth Factor

作　　者：何云[1] 王晨虹[1] 石泽真[1] 宋彩珍 钟梅[3] 

机构地区：[1]深圳市妇幼保健院妇产科,广东深圳518028 [2]武汉市武昌医院检验科,武汉430071 [3]南方医科大学附属南方医院妇产科,广州510515

出　　处：《医学综述》2011年第15期2394-2396,共3页Medical Recapitulate

摘　　要：目的研究胎盘生长因子(PlGF)及临床生化指标在正常妊娠和子痫前期(PE)(轻度、重度)母体外周血中表达差异。方法选取PE轻度孕妇15例、PE重度孕妇21例,17例正常单胎孕妇(对照组),用ELISA方法测定其外周血中PlGF的水平,常规测量各项生化指标。结果正常对照组、轻度PE组、重度PE组血清中PlGF分别为(147.55±86.66)(、62.41±38.86)(、35.91±24.28)ng/L,随着PE的病情加重,血清PlGF逐渐降低。重度PE组血尿酸、肌酐、β2微球蛋白水平较正常对照组明显升高(P<0.01),白蛋白水平较正常对照组低(P<0.01)。结论 PlGF在PE组孕妇的外周血中表达降低,与疾病的严重程度相关。血清PlGF可以作判断PE疾病的指标。Objective To investigate the expression differences of placenta growth factor（PlGF） and clinical biochemical indicators in maternal peripheral blood of normal pregnancy and preeclampsia（mild,severe） group.Methods PlGF concentration of serum was measured by enzyme linked immunosorbent assay（ELISA） in 36 preeclampsia patients（15 cases of mild preeclampsia and 21 cases of severe preeclampsia）and 17 normal pregnant women.Clinical biochemical indicators data were collected.Results The serum level of PlGF of patients with mild preeclampsia group was（62.41±38.86）ng/L,severe preeclampsia was（35.91±24.28）ng/L,control group was（147.55±86.66）ng/L.The results showed that the serum PlGF levels of preeclampsia group were lower than those of the control group and there were significant differences among the mild preeclampsia group,sever preeclampsia group and control group.The concentration of serum uric acid,β2 microglobulin and serum creatinine in severe preeclampsia group were higher than those in the control group（P0.01）;concentration of plasma albumin was lower than the control group（P0.01）.Conclusion Lower maternal serum PlGF in preeclampsia patients is related to the severity of the disease.Serum PlGF can be used as an indicator of preeclampsia.

关 键 词：胎盘生长因子 子痫前期 酶联免疫吸附测定 诊断 

分 类 号：R714.24[医药卫生—妇产科学]