三氯氧磷催化N-烷基化制备N-乙基苯胺和N,N-二乙基苯胺  

Phosphorus Oxychloride Catalytic N-alkylation for the Synthesis of N-ethyl Aniline and N,N-diethylAniline

作　　者：王波[1] 卢春山[1] 张群峰[1] 丰枫[1] 袁俊峰[1] 李小年[1] 

机构地区：[1]浙江工业大学工业催化研究所绿色化学合成技术国家重点实验室培育基地,杭州310032

出　　处：《化工生产与技术》2011年第4期21-24,42,共5页Chemical Production and Technology

摘　　要：以三氯氧磷为催化剂,由苯胺和乙醇反应制备了N-乙基苯胺和N,N-二乙基苯胺,考察了温度、压力、催化剂用量、醇胺摩尔比、反应时间等因素对该反应的影响。结果表明,三氯氧磷催化苯胺和乙醇反应的较佳工艺条件为:V(C6H7N):V(C2H5OH):V(POCl3)=55:70:2,温度493 K,N2压力4.0 MPa,反应时间8 h;当苯胺的转化率为100%时,N,N-二乙基苯胺的收率为67.82%、N-乙基苯胺和N,N-二乙基苯胺的总收率达95%以上。讨论了三氯氧磷催化苯胺和乙醇反应的机理。The paper introduces the way to synthesize N-ethyl aniline and N,N-diethyl aniline from aniline and ethanol using phosphorus oxychloride as catalyst.The effects of reaction temperature,pressure,mass of catalyst,the molar ratio of ethanol to aniline,and reaction time on the yield of desired products were investigated.The experimental results indicated that N,N-diethyl aniline yield of 67.82% with the total yield of N-ethyl aniline and N,N-diethyl aniline of 95% was obtained when the conversion of aniline was 100%,under optimal reaction condition as follows: V(C6H7N):V(C2H5OH):V(POCl3)=55:70:2,reaction temperature 493 K,N2 pressure 4.0 MPa,reaction time 8 h.Furthermore,the reaction mechanism of N-alkylation for the synthesis of N-ethyl aniline and N,N-diethyl aniline was discussed.

关 键 词：三氯氧磷 苯胺 乙醇 催化 N-烷基化 

分 类 号：TQ246.31[化学工程—有机化工]