丹参水溶性成分的地域分布特点分析  

Analysis on Geographical Distribution of Hydrophilic Components in Radix Salviae Miltiorrhizae

作　　者：杨新杰[1] 万德光[1] 刘敏[1] 林贵兵[1] 王金燕[1] 严铸云[1] 

机构地区：[1]成都中医药大学药学院中药材标准化教育部重点实验室,成都610075

出　　处：《天然产物研究与开发》2011年第4期684-688,共5页Natural Product Research and Development

基　　金：国家十一五科技支撑计划项目(2006BAI09B03-4)

摘　　要：分析全国不同产地丹参中水溶性成分的含量变化情况及其地域分布特点。采用HPLC法测定不同产地丹参水溶性成分的含量,运用SAS统计软件分析丹参水溶性成分相关性及其地域分布特点。回归分析表明,丹参素与丹酚酸A含量呈负相关,原儿茶醛与迷迭香酸含量呈负相关,咖啡酸与丹参素含量呈负相关,丹酚酸B与丹酚酸A、丹参素含量呈正相关。聚类分析表明,三个野生药材与山东和河南大部分产地、四川中江栽培药材水溶性成分较高聚为一类。建议丹参药材中丹参素≥0.14%,原儿茶醛≥0.01%,咖啡酸≥0.01%,迷迭香酸≥0.17%,丹酚酸B≥3.0%,丹酚酸A≥0.01%。丹参的水溶性成分呈现地域性差异,传统道地产区的含量较高。Analyzing the content change of hydrophilic constituents and it＇s geographical distribution in Salvia miltiorrhira from different producing area around china.Determining content of hydrophilic constituents in S.miltiorrhira from different producing area by HPLC and using SAS to analyze correlation about hydrophilic constituents in S.miltiorrhira and it＇s geogrofic distribution.Regression analysis shows that content of Danshensu and salvianolic acid A present negative correlation,protocatechuic aldehyde and rosemarinic acid present negative correlation,caffeic acid and Danshensu present negative correlation,salvianolic acid B and salvianolic acid A and Danshensu showing positive correlation.Cluster Analysis shows that three wild medicinal herbs and the cultivated species in most producing area of Shandong and Hebei province and Zhongjiang in Sichuan are one kind.Their content of hydrophilic constituents are high.We suggested that Danshensu should greater than or equal to 0.14%,protocatechuic aldehyde should greater than or equal to 0.01%,caffeic acid should greater than or equal to 0.01%,rosemarinic acid should greater than or equal to 0.17%,salvianolic acid B should greater than or equal to 3.0%,and salvianolic acid A should greater than or equal to 0.01%.There are differences in hydrophilic constituents in S.miltiorrhira between different producting areas,especially higher in traditional and original location.

关 键 词：丹参 丹参素 原儿茶醛 咖啡酸 迷迭香酸 丹酚酸B 丹酚酸A HPLC 

分 类 号：R284.1[医药卫生—中药学]