海洋沉积物来源链霉菌属次生代谢产物及其生物活性研究进展  

Research Advances on Secondary Metabolites and Bioactivity for the Marine Sediment-Derived Streptomyces

作　　者：黄永中[1] 罗雄明[2] 王建华[1] 

机构地区：[1]重庆大学生物工程学院,重庆400044 [2]中国科学院南海海洋研究所,广州510301

出　　处：《天然产物研究与开发》2011年第4期758-766,共9页Natural Product Research and Development

基　　金：国家科技支撑计划项目(2007BAD51B05);重庆市科技攻关计划项目(CSTC2009AB1043);国家青年基金项目(41006091)

摘　　要：海洋沉积物是营养较为丰富的微生物栖息地,近年来从海洋沉积物中分离培养出了大量海洋链霉菌,从中还发现了一些新的属种。人们已从海洋沉积物来源链霉菌属中发现了许多具有药用价值的活性化合物,有力推动了海洋天然产物化学的发展,并为新药研发提供基础。本文就海洋沉积物来源链霉菌属次生代谢产物的结构类型及其生物活性进行简要综述。Marine sediment is a abundant nutrition habitat for microbes.In recent years,a large number of marine streptomyces were isolated from marine sediments,of which some new genera and species were also obtained.Many medicinal active compounds have been found from the marine sediment-derived streptomyces,which promoted the development of marine natural product chemistry and provided the basis for research and development of new drugs.In this paper,types of structures and bioactivities of secondary metabolites produced by marine sediment-derived streptomyces have been briefly reviewed.

关 键 词：海洋沉积物 链霉菌属 次生代谢产物 生物活性 

分 类 号：R284.2[医药卫生—中药学]