吸毒人群口腔假丝酵母药物敏感性分析  

Antifungal susceptibility of oral Candida species among drug abusers

作　　者：袁有华[1] 白丽[1] 武有聪[1] 钱金栿[2] 刘奇[1] 郭利军[1] 

机构地区：[1]大理学院基础医学院医学微生物及免疫学教研室,云南大理671000 [2]大理学院药学院

出　　处：《中国公共卫生》2011年第9期1137-1139,共3页Chinese Journal of Public Health

基　　金：国家自然科学基金(C30260005);大理学院高层次人才基金(KY430440)

摘　　要：目的了解吸毒人群口腔假丝酵母对常用抗真菌药物的敏感性,为临床治疗假丝酵母病提供参考资料。方法采用美国临床标准化实验委员会推荐的微量稀释法测定75株假丝酵母对4种常用抗真菌药物两性霉素B(Amb)、5-氟胞嘧啶(5-FC)、氟康唑(FCZ)和酮康唑(KETO)的药物敏感性。结果 75株吸毒人群口腔假丝酵母对Amb、5-FC、FCZ和KETO的耐药率分别为0、4%、8%和13.3%;对FCZ和KETO的交叉耐药率为8%;非白色假丝酵母对FCZ的耐药率为23.5%,对KETO的耐药率为43.2%,高于白色假丝酵母的3.45%和5.2%,差异有统计学意义(P<0.05),2种假丝酵母对5-FC和Amb的耐药率差异无统计学意义。结论吸毒人群口腔假丝酵母对Amb和5-FC的敏感性高于对FCZ和KETO;口腔假丝酵母对FCZ、KETO和5-FC有天然耐药株和对唑类药物的天然交叉耐药株,且非白色假丝酵母对FCZ和KETO的耐药率及交叉耐药率高于白色假丝酵母。Objective To examine the antifungal susceptibility of oral Candida species among drug abusers and to provide reference for treatment of candidasis in clinic. Methods Totally 75 oral Candida species were tested for susceptibility of amphotericine B（Amb） ,5-flurocytosine（5-FC） ,fluconazole（FCZ） ,and ketonazole（KETO） with microdilution antifungal susceptibility test recommended by National Committee for Clinical Laboratory Standards （NCCLS）. Results The resistant rate of 75 oral Candida species from drug abusers for Amb, 5-FC, FCZ, and KETO was 0,4%, 8 %, and 13.3 %, respectively. The crosswise resistant rate of the strains for FCZ and KETO was 8%. The resistant rates of non-Candida albicans to FCZ（23.5% ） and KETO（43.2% ） were higher than those of Candida albicans with a significant difference. But the resistant rates to 5-FC and Arab were not significantly different for the two Candidas groups. Conclusion The susceptibility of oral Candida species from drug abusers for Amb and 5-FC is higher than that of FCZ and KETO. Among the oral Candida species from drug abusers, both Candida strains resistant to FCZ, KETO ,5-FC and Candida strains resistant crosswise to FCZ and KETO are prevalent. Besides, the resistant rate and crosswise resistant rate of non-Candida albicans to FCZ and KETO is higher than those of Candida albicans.

关 键 词：假丝酵母 药物敏感性 吸毒人群 

分 类 号：R195[医药卫生—卫生统计学]