原因不明复发性自然流产患者主动免疫治疗前后血清IL-6、IL-10、TNF-α水平变化  

The level changes of serum IL-6,IL-10,TNF-α in patients with unexplained recurrent spontaneous abortion before and after active immunotherapy

作　　者：王力[1] 闻姬[1] 

机构地区：[1]山东中医药大学第二附属医院,济南250001

出　　处：《山东医药》2011年第30期11-12,共2页Shandong Medical Journal

摘　　要：目的观察原因不明复发性自然流产(URSA)患者主动免疫治疗前后血清IL-6、IL-10、TNF-α水平的变化。方法对50例URSA患者(URSA组)采用主动免疫治疗。选择正常非妊娠妇女50例为正常非孕组,行药物流产或人工流产的妇女50例为对照组。采用ELISA法分别检测URSA组治疗前、治疗1个疗程后2周、妊娠后孕50 d及正常非孕组、正常妊娠组的血清IL-6、IL-10、TNF-α。结果 URSA组治疗前血清IL-6、IL-10、TNF-α水平与正常非孕组相比,P均<0.05。URSA组主动免疫治疗后IL-6、IL-10水平较治疗前升高,TNF-α水平下降(P均<0.05),三种细胞因子水平与正常非孕组相比,P均>0.05。URSA组免疫治疗后成功妊娠的30例血清IL-6、IL-10、TNF-α水平与对照组相比,P均>0.05。结论 URSA患者血清IL-6、IL-10水平下降、TNF-α水平升高与URSA发病密切相关。主动免疫治疗可上调IL-6、IL-10水平,下调TNF-α水平,URSA免疫治疗后妊娠者IL-6、IL-10、TNF-α水平恢复正常。Objective To observe level changes of serum IL-6,IL-10,TNF-α in patients with unexplained recurrent spontaneous abortion（URSA） before and after active immunization.Methods 50 cases of URSA patients（URSA group） with active immunotherapy were selected.Selected 50 cases of normal non-pregnant women as the normal non-pregnant group,and 50 cases of women with medical abortion as the control group.Serum IL-6,IL-10,TNF-α of 3 groups were detected by ELISA at before URSA treatment,2 weeks after a course of treatment,pregnancy after 50 d,respectively.Results Serum IL-6,IL-10,TNF-α levels of URSA group with pretreatment compared with normal non-pregnant group,all P0.05.IL-6,IL-10 levels of URSA group with active immunotherapy were higher than before treatment,TNF-α levels were decreased（all P0.05）,levels of both three cytokines compared with normal non-pregnant group,all P0.05.Serum IL-6,IL-10,TNF-α levels of 30 cases in URSA group after a successful pregnancy with active immunotherapy compared with the control group,all P0.05.Conclusions The decline of levels of serum IL-6,IL-10 are closely related with the URSA.Active immunotherapy can increase IL-6,IL-10 levels and lower TNF-α levels.After URSA immunotherapy,IL-6,IL-10,TNF-α levels return to normal.

关 键 词：自然流产 主动免疫疗法 白细胞介素 肿瘤坏死因子 

分 类 号：R714.21[医药卫生—妇产科学]