亚慢性铝暴露对雏鸡肾脏结构与功能的影响  

Effects of Aluminum Intoxication on Structure and Function of Kidney in Chickens

作　　者：李艳飞[1] 胡崇伟[2] 冯国锋[1] 王明河[1] 

机构地区：[1]东北农业大学动物医学学院,黑龙江哈尔滨150030 [2]福建农林大学动物科学学院,福建福州350002

出　　处：《中国家禽》2011年第16期10-12,共3页China Poultry

基　　金：黑龙江省自然科学基金(C200935)

摘　　要：采用连续腹腔注射等体积不同浓度梯度三氯化铝法,建立不同程度雏鸡亚慢性铝中毒模型,通过对血清和肾脏中铝含量、血清中肾功能指标肌酐(Cr)和尿素氮(BUN)含量测定,并应用光镜技术观察肾脏组织学结构,探讨染铝对雏鸡肾脏结构与功能的影响。结果表明:各染铝组血清和肾脏中铝含量以及血清中Cr和BUN含量均显著高于对照组(P<0.05;P<0.01),且存在剂量效应关系。光镜下,低剂量染铝组肾小球轻度肿胀,肾小管和近曲小管未见明显变化。中、高剂量染铝组肾小球肿胀,肾小球内细胞数量增多,肾小管浊肿,近曲小管上皮细胞肿胀。上述结果说明,亚慢性铝中毒可致雏鸡肾脏结构及功能受损。The model of different level′s sub-chronic aluminum intoxication in chickens was established by continuous peritoneal injection with different gradient aluminum trichloride （AlCl3）. The aluminum （Al） concentration in serum and kidney and the contents of creatinine （Cr） and blood urea nitrogen （BUN） in serum were detected and the structure of kidney was observed by optical microscope. The results showed that the Al concentration in serum and kidney and the contents of Cr and BUN in serum were significantly higher in chichens with aluminum intoxication than those in the control ones and there were dose-effect relationship with aluminum trichloride. Histopathologically,in low dose group,acinus renis swelled mildly and there were no apparent pathological change in nephric tubule and proximal convoluted tubule. In middle and high dose group,acinus renis swelled,glomerular cells increased,nephric tubule cloudy swelled,epithelial cell of proximal convoluted tubule swelled. The results indicated that sub-chronic aluminum intoxication caused pathological and functional injury in kidney of chickens.

关 键 词：雏鸡 铝中毒 肾功能 组织病理学 

分 类 号：S858.31[农业科学—临床兽医学]