鹅掌楸碱的研究进展  

Research Progress on Liriodenine

作　　者：刘延成[1,2] 陈振锋[1,2] 彭艳[1,2] 梁宏[1,2] 

机构地区：[1]广西师范大学化学化工学院 [2]药用资源化学与药物分子工程教育部重点实验室,广西桂林541004

出　　处：《林产化学与工业》2011年第4期109-116,共8页Chemistry and Industry of Forest Products

基　　金：国家自然科学基金资助项目(20861002);广西自然科学基金(0991003);广西教育厅基金资助项目(200807MS014)

摘　　要：综述了鹅掌楸碱这一典型的氧化阿朴啡碱在其植物化学、药理学及其抗肿瘤活性与机制方面的研究进展。鹅掌楸碱广泛分布于不同科属的天然植物中,但含量均较低;其在抗肿瘤、抗细菌、抗真菌、杀锥虫以及抗老年痴呆等方面表现出广泛的药理活性,而其显著的抗肿瘤活性则是基于氧化阿朴啡母核的超共轭平面结构;同时,结合作者的近期研究成果,介绍了基于鹅掌楸碱的药物无机化学研究新方向的前期进展。The research progress on the phytochemistry,pharmacology,as well as antitumoral activity and mechanism of liriodenine was reviewed,which is a kind of typical oxoaporphine alkaloid.Liriodenine widely distributes in many natural plants of a series of families and genera,but the content is very low.Liriodenine exhibits extensive pharmacological activities,such as antitumoral,antibacterial,antifungal and trypanocidal activities,as well as anti-alzheimer′s disease.It is seen that the significant antitumoral activity should be ascribed to the hyperconjugational planar structure of oxoaporphine as parent nucleus.Moreover,the pro-phase research progress as the rise of medicinal inorganic chemistry of liriodenine was also briefly introduced based on the authors＇ achieved research efforts.It could provide new strategy for the expanded research and application of liriodenine.

关 键 词：鹅掌楸碱 植物化学 药理活性 抗肿瘤机制 药物无机化学 

分 类 号：TQ351[化学工程] R284[医药卫生—中药学]