激光法测定硝唑尼特结晶介稳区间  

Measurement of Crystallization Metastable Zone of Nitazoxanide Using the Laser Scattering Method

作　　者：赵地顺[1] 吕斌[2] 寇成[1] 杨洁[1] 董兰芬[1] 张妍[1] 

机构地区：[1]河北科技大学化学与制药工程学院,石家庄050018 [2]河北科技大学理学院,石家庄050018

出　　处：《应用化学》2011年第9期1063-1066,共4页Chinese Journal of Applied Chemistry

摘　　要：用激光法测定了不同温度下硝唑尼特在N,N-二甲基甲酰胺(DMF)、二甲基亚砜(DMSO)、甲醇和丙酮4种溶剂体系中的溶解度与超溶解度,得到硝唑尼特在不同溶剂和不同温度下的介稳区宽度。结果表明,硝唑尼特在4种溶剂体系中的溶解度、超溶解度和介稳区宽度随温度升高逐渐增大。在相同温度下,硝唑尼特在DMF、DMSO、甲醇和丙酮中介稳区宽度关系为:丙酮<DMSO<甲醇<DMF。The saturated and supersaturated characteristics of nitazoxanide in DMF,DMSO,methanol and acetone at different temperatures were investigated by using the laser detection technique.The crystallization metastable zone widths of nitazoxanide were obtained at different temperatures in the above four solvents.The results indicated that the solubility,supersolubility and the metastable zone width of nitazoxanide enhance with increasing temperature.At the same temperature,the metastable zone width of nitazoxanide relations as follows：acetoneDMSOmethanolDMF.

关 键 词：硝唑尼特 溶解度 超溶解度 介稳区宽度 

分 类 号：O626.1[理学—有机化学]