大黄总提物的大鼠亚急性毒性  

Subacute Toxicity of Total Extract of Rhubarb in Rats

作　　者：柴宝娟[1] 李祥[1] 陈建伟[1] 

机构地区：[1]南京中医药大学药学院,南京210046

出　　处：《药学与临床研究》2011年第4期322-324,共3页Pharmaceutical and Clinical Research

基　　金：江苏省高校优势学科建设工程资助项目

摘　　要：目的:观察不同剂量大黄总提物对SD大鼠的肝肾毒性,为临床合理应用大黄提供依据。方法:大黄总提物以3、6、12 g.kg-1(生药)灌胃,每天给药1次,连续30 d。结果:高剂量组大鼠给药30 d后精神萎靡,尿液深黄色,排稀便,体重增长缓慢,雄性大鼠体重显著低于同期对照组。高剂量组ALT、AST显著升高,肝脏出现不同程度的水肿,肾脏未见病变。结论:在该实验条件下,给药30 d后高剂量大黄总提物主要对肝脏产生毒性作用。Objective： To investigate the toxicity of various doses of rhubarb on kidney and liver of SD rats in order to guide rational medication of rhubarb in clinic.Methods： Total extract of rhubarb was administered to rats at oral doses of 3,6 and 12 g·kg-1（crude drug） once daily for 30 days.Results： The rats from the high-dose group showed depression and diarrhea.The colour of urine was deep yellow and body weight increased slowly.Body weight of male rats increased more slowly than the rats in normal control group.In high-dose group,blood chemical tests revealed a notable increase in AST and ALT.The liver of rats from high-dose group showed different levels of edema.And a month use of high dose of rhubarb showed no harm to the kidney.Conclusion： Rats given 12 g·kg-1 of crude rhubarb for 30 days showed hepatotoxicity.

关 键 词：大黄 肝毒性 肾毒性 

分 类 号：R965.3[医药卫生—药理学]