离子对HPLC法测定五维牛磺酸口服液中4种水溶性维生素  

Determination of Four Vitamins in Five Vitamins and Taurine Oral Solution by IP-HPLC

作　　者：顾丽娟[1] 杨大龙[2] 冷柏榕[2] 严相平[2] 

机构地区：[1]南京医科大学第一附属医院药剂科,南京210029 [2]南京工业大学江苏省药物研究所,南京210009

出　　处：《药学与临床研究》2011年第4期381-382,共2页Pharmaceutical and Clinical Research

摘　　要：建立HPLC法测定五维牛磺酸口服液中维生素B1、B2、B6和烟酰胺的含量。采用C18柱,甲醇-0.01mol·L-1庚烷磺酸钠溶液(含0.1%冰醋酸)为流动相,检测波长273 nm。平均回收率分别为99.8%、99.7%、99.4%和99.4%。An HPLC method was established for nicotinamide in Five Vitamins and Taurine Oral liquid. A methanol-0.01 mol·L^-1 heptanesulfonic acid sodium salt wavelength was 273 nm. The average recoveries of vitamin the determination of C18 coltlmn was used, vitamin B1, B2, B6 and with the mobile phase of （contain 0.1% glacial acetic acid）. The detection B1, B2, B6 and nicotinamide were 99.8%, 99.7%,99.4% and 99.4%, respectively.

关 键 词：维生素B1 维生素B2 维生素B6 烟酰胺 高效液相 色谱法 

分 类 号：R927.2[医药卫生—药学]