110例住院患者甲型流感血清抗体水平分析  

Investigation of level of antibody against influenza A virus in 110 hospital patients

作　　者：王慧敏[1,2] 陈杭薇[1] 尤兰华[1] 李雪辉[1] 魏娟[1] 

机构地区：[1]北京军区总医院,北京100700 [2]山西医科大学,在读研究生山西太原030001

出　　处：《中国热带医学》2011年第8期947-948,共2页China Tropical Medicine

基　　金：全军"十一五"科技攻关课题(No.06G026)

摘　　要：目的分析呼吸道感染住院患者甲型流感病毒（FluA）抗体水平。方法采集2009年10月1日~2011年2月1日收住北京军区总医院呼吸科110例住院患者的双份血清,应用血凝抑制试验（HI）测定双份血清FluA的血凝抑制（HI）抗体。结果呼吸道感染住院患者新型甲型H1N1流感确诊病例主要集中在2009年10月~12月,随后以混合感染形式与季节性H3N2和季节性H1N1散发存在。新型H1N1的检出率为3.6%（4/110）,季节性H1N1检出率2.7%（3/110）,季节性H3N2检出率6.4%（7/110）,FluA混合感染检出率4.5%（5/110）。抗体滴度≥4倍增高患者仅表现为原有肺部疾病加重者占8/19,抗体滴度2倍增高患者仅表现为原有肺部疾病加重占10/23。结论在流感大流行期间,季节性流感不容忽视;不仅要关注流感样病例,更应注意有基础肺病患者原有症状加重可能是感染流感的唯一表现。Objective To explore influenza A virus antibody titres in inflennza A patients between1 October 2009 and 1 February 2011.Methods Duplicate serum samples were collected from 110 influenza A patients in Beijing Military Garrison General Hospital.HI antibody to influenza A virus was detected with the hemagglutination inhibition（HI）test.Results The confirmed inpatients cases of novel influenza A（H1N1） mainly concentrated between October 2009 and December 2009,and then most of the cases were mixed infections with seasonal influenza A（H3N2） and inluenza A（H1N1）.Novel H1N1 detection rate was 3.6%（4/110）;seasonal H1N1detection rate was 2.7%（3/110）;seasonal H3N2 detection rate was 6.4%（7/110）,FluA mixed infection rate was 4.5%（5/110）.In the patients with the double antibody titre increased by ≥4 folds,presenting original lung disease aggravated accounted for 8/19 and in those with the double antibody titre increased 2 folds presenting original lung disease aggravated accounted for 10/23.Conclusion After 2009 New influenza（H1N1） pandemic,the seasonal distribution of influenza A pandemic can not be ignored;Attention be paid to influenza-like illness,and it should be noted that original symptoms of lung disease may be the only manifestation of influenza infection.

关 键 词：甲型流感病毒 血凝抑制试验 抗体 

分 类 号：R521.1[医药卫生—内科学]