Molecular Iodine Promoted Synthesis of New Pyrido[2,3-d]pyrimidin-4-ols  

作　　者：王喜存 梁军灵 权正军 白林 

机构地区：[1]Key Laboratory of Eco-Environment-Related Polymer Materials, Ministry of Education, Gansu Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, China [2]Institute of Green Chemistry Experiment and Teaching, Lanzhou City University, Lanzhou, Gansu 730070, China

出　　处：《Chinese Journal of Chemistry》2011年第8期1646-1650,共5页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （No. 20902073）, the Natural Science Foundation of Gansu Province （No. 096RJZA116） and Scientific and Technological Innovation Engineering Program of Northwest Normal University （No. nwnu-kjcxgc-03-64）.

摘　　要：A highly efficient synthesis of novel pyrido[2,3-d]pyrimidin-4-ols was developed via an iodine-catalyzed tandem oxidative cyclization under focused microwave irradiation. Pyrido[2,3-d]pyrimidin-4-ols were obtained from easily available 2-amino-4-aryl-6-arylnicotinamides and benzylic amines with good to excellent yields.A highly efficient synthesis of novel pyrido[2,3-d]pyrimidin-4-ols was developed via an iodine-catalyzed tandem oxidative cyclization under focused microwave irradiation. Pyrido[2,3-d]pyrimidin-4-ols were obtained from easily available 2-amino-4-aryl-6-arylnicotinamides and benzylic amines with good to excellent yields.

关 键 词：iodine catalysis oxidative cyclization microwave irradiation pyrido[2 3-d]pyrimidin-4-ol 

分 类 号：O626.32[理学—有机化学] TQ252.4[理学—化学]