In（OTf）3-Catalyzed Synthesis of Functionalized 1,5-Benzodiazepines from o-Phenylenediamine and Alkyl Propiolates under Solvent-Free Reaction Conditions  

作　　者：吴海生 杨进 王磊 

机构地区：[1]Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, China [2]State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

出　　处：《Chinese Journal of Chemistry》2011年第8期1721-1726,共6页中国化学（英文版）

基　　金：Project supported bythe National Natural Science Foundation of China（Nol 20972057）.

摘　　要：A simple, environmental-friendly, and practical method for the synthesis of benzodiazepine derivatives through a reaction of substituted o-phenylenediamines with alkyl propiolates has been developed. The reactions generated the 1,5-benzodiazepines in good to excellent yields in the presence of catalytic amount of In（OTf）3 under sol- vent-free reaction conditions.A simple, environmental-friendly, and practical method for the synthesis of benzodiazepine derivatives through a reaction of substituted o-phenylenediamines with alkyl propiolates has been developed. The reactions generated the 1,5-benzodiazepines in good to excellent yields in the presence of catalytic amount of In（OTf）3 under sol- vent-free reaction conditions.

关 键 词：benzodiazepines O-PHENYLENEDIAMINES alkyl propiolates In（OTf）3 SOLVENT-FREE 

分 类 号：TQ246.31[化学工程—有机化工] O623.624[理学—有机化学]