One-pot Combinatorial Synthesis of Benzo[4,5]imidazo- [1,2-a]thiopyrano[3,4-dJpyrimidin-4（3H）-one Derivatives  

作　　者：沈士德 张红红 杨伟华 于晨侠 姚昌盛 

机构地区：[1]Xuzhou Institute of Architectural Technology, Xuzhou, Jiangsu 221116, China [2]School of Chemistry & Chemical Engineering, Xuzhou Normal University, Xuzhou, Jiangsu 221116, China [3]Key Laboratory of Biotechnologyfor Medicinal Plants, Xuzhou Normal University, Xuzhou, Jiangsu 221116, China

出　　处：《Chinese Journal of Chemistry》2011年第8期1727-1731,共5页中国化学（英文版）

基　　金：Project supported by the Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions （09KJA430003）, Natural Science Foundation of Xuzhou City （XM09B016）, Graduate Foundation of Xuzhou Normal University （09YLB030） and Qing Lan Project （08QLT001）.

摘　　要：A series of novel fused tetracyclic benzo[4,5]imidazo[1,2-a]thiopyrano[3,4-d]pyrimidin-4（3H）-one derivatives were synthesized via the reaction of aryl aldehyde, 2H-thiopyran-3,5（4H,6H）-dione, and 1H-benzo[d]imidazol-2- amine in glacial acetic acid. This protocol features mild reaction conditions, high yields and short reaction time.A series of novel fused tetracyclic benzo[4,5]imidazo[1,2-a]thiopyrano[3,4-d]pyrimidin-4（3H）-one derivatives were synthesized via the reaction of aryl aldehyde, 2H-thiopyran-3,5（4H,6H）-dione, and 1H-benzo[d]imidazol-2- amine in glacial acetic acid. This protocol features mild reaction conditions, high yields and short reaction time.

关 键 词：benzo[4 5]imidazo[1 2-a]thiopyrano[3 4-d]pyrimidin-4（3H）-one multicomponent reactions combi-natorial chemistry 

分 类 号：TQ452[化学工程—农药化工] TQ455.47