Synthesis of N1-3-{（4-Substituted aryl-3-chloro-2-oxo- azetidine）-iminocarbamyl}-propyl-6-nitroindazole Derivatives and Their Biological Significance  

作　　者：Samadhiya, Pushkal Sharma, Ritu Srivastava, Santosh K. Srivastava, Savitri D. 

机构地区：[1]Synthetic Organic Chemistry Laboratory, Department of Chemistry, Dr. H. S. Gour University (A Central Univer- sity), Sagar, M.P. 470003, India

出　　处：《Chinese Journal of Chemistry》2011年第8期1745-1752,共8页中国化学（英文版）

摘　　要：Synthesis of N1-3-{（4-substitute daryl-3-chloro-2-oxo-azetidine）-iminocarbamyl}-propyl-6-nitroindazole 4a-- 4s was conducted by a conventional method. All the compounds were synthesized and characterized by IR, 1H NMR, 13C NMR, FAB-Mass techniques and chemical methods. All the final synthesized compounds were evaluated for their antimicrobial activity and antitubercular activity with MIC values against some selected microorganisms.Synthesis of N1-3-{（4-substitute daryl-3-chloro-2-oxo-azetidine）-iminocarbamyl}-propyl-6-nitroindazole 4a-- 4s was conducted by a conventional method. All the compounds were synthesized and characterized by IR, 1H NMR, 13C NMR, FAB-Mass techniques and chemical methods. All the final synthesized compounds were evaluated for their antimicrobial activity and antitubercular activity with MIC values against some selected microorganisms.

关 键 词：synthesis 6-nitroindazole 2-azetidinone biological activity 

分 类 号：TQ423.115[化学工程] S482.8[农业科学—农药学]