不同透析膜对尿毒症患者内皮素-1、血清胱抑素C的影响  

Effects of Dialysis Membranes on ET-1 and Serum Cystatin C in Uremic Patients

作　　者：樊雨良 刘沁[1] 陆遥[1] 吴秀琴[1] 金蕾[2] 

机构地区：[1]上海市黄浦区中心医院肾内科,上海200002 [2]上海交通大学科技发展实验室,上海200002

出　　处：《中国现代医生》2011年第25期63-64,69,共3页China Modern Doctor

摘　　要：目的比较不同透析膜、不同血液净化方式对血透患者血管活性物质的清除。方法聚砜膜血液透析滤过HDF组用放免法测定透析前后内皮素-1(ET-1)、尿素氮(BUN)、肌酐(SCr)乳胶指标,用增强免疫比浊法测定血清胱抑素C(Cys-c)等指标。双醋酸膜(FB-130)HD组也用放免法测定透析前后ET-1、BUN、SCr乳胶指标,用增强免疫比浊法测定血清Cys-c等指标。1个月后复查透析前ET-1等指标。结果聚砜膜HDF组单次透析ET-1血透后低于血透前(P<0.05),而HD组透析前后无明显差异。聚砜膜HDF组1个月后ET-1均较前有所下降(P<0.01)。结论 HDF可部分清除血透患者血浆中ET-1含量,HDF可减轻炎症反应和组织损伤。维持性血透患者定期进行HDF治疗,能加强治疗效果,提高生存质量。Objective To compare the clearance of vasoactive substances of different dialysis membranes and different blood purification for patients on hemodialysis. Methods Polysulfone membrane hemodiafihration HDF group which measured indicators of radioimmunoassay before and after dialysis, endothelin （ET-1）, blood urea nitrogen （BUN）, creatinine （Serum） and Latex and measured indicators by enhanced immunoturbidimetric method for measuring serum cystatin C （Cys-c） and other indicators. Review ET-1 and other indicators after one month before dialysis. Diacetate membrane （FB-130） HD group, also measured by radioimmunoassay before and after dialysis, endotbelin （ET-1）, urea nitrogen （BUN）, creatinine （SCr） latex indicators, with the enhanced immunoturbidimetric method for measuring serum cystatin C （Cys-c） and other indicators. ET-1 will be reviewed of pre-dialysis and other indicators after one month. Results HDF group＇ s ET-1 decreases （P 〈 0.05） after hemodialysis than before hemodialysis which tested by Polysulfone membrane dialysis single, while the HD group was no significant difference before and after dialysis. Polysulfone membrane HDF group＇ s ET-1 decreased （P 〈 0.01） than a month before. Conclusion HDF can clear part of the plasma ET-1 levels in hemodialysis patients, HDF can reduce inflammation and tissue damage. Regular hemodialysis patients using HDF treatment can enhance treatment effect and improve clualitv of life.

关 键 词：血液透析滤过 内皮素-1 聚砜膜 血清胱抑素C 

分 类 号：R692.5[医药卫生—泌尿科学]