生长因子对肌腱细胞表型及分化的影响  

Effect of Various Growth Factors on Tenocyte′s Phenotypes and Differentiation

作　　者：邱轶伟[1] 朱理玮[1] 

机构地区：[1]天津医科大学总医院普通外科,天津300052

出　　处：《医学综述》2011年第16期2414-2417,共4页Medical Recapitulate

摘　　要：目前对于肌腱细胞体外培养的难点较为突出,其中一个难点为,肌腱细胞在体外长时间培养难以维持其表型的表达,继而影响其分化;另外一个难点是,在培养基内添加了大量的胎牛血清,而大量胎牛血清的使用会造成动物-人之间的疾病传播。已有研究显示在培养基中加入不同的生长因子以减少胎牛血清的使用并促进肌腱细胞的分化。本综述较为全面地总结了几种肌腱细胞较为重要的表型和分化标志物以及几种维持肌腱细胞表型的生长因子。Currently the difficulties of tendon tissue engineering are noticeable,one of which is to maintain the phenotype of the tenocytes during long in vitro culture and to reduce the fetal bovine serum use in in vitro culture,the massive use of which may cause animal-human disease spread.Several studies have demonstrated the importance of adding growth factors in culture media to maintain the tenocytes′ phenotype.Here is to review the tenocytes′ markers and the growth factors which may maintain tenocyte phenotype as well as promote tenocytes differentiation in in vitro culture.

关 键 词：肌腱细胞 表型标志物 生长因子 

分 类 号：R687.2[医药卫生—骨科学]